Desipramine hydrochloride CAS: 58-28-6
MF: C18H22N2•HCl
MW: 302.84

Desipramine hydrochloride (CAS 58-28-6)

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Desipramine hydrochloride is rated 5.0 out of 5 by 2.
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別名: N-(gamma-Methylaminopropyl)iminodibenzyl hydrochloride
アプリケーション: Desipramine hydrochloride is an inhibitor of norepinephrine, serotonin, and dopamine transporters
CAS 番号: 58-28-6
Purity: ≥98%
Molecular Weight: 302.84
Molecular Formula: C18H22N2•HCl
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
* Refer to Certificate of Analysis for lot specific data (including water content).
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Desipramine HCl is a selective inhibitor of noradrenaline the transporters norepinephrine transporter (SLC6A2 or NET; Ki = 4 nM), serotonin transporter (ST or SERT; Ki = 61 nM), and dopamine transporter (DAT; Ki = 78,720 nM). This compound is a potent inhibitor of the norepinephrine transporter, and also blocks serotonin re-uptake. This compound has also been shown to reverse the pro-apoptotic effect of chronic unpredictable mild stress in the rat cerebral cortex, although it induces apoptosis in several cancer cell lines. It has also been shown to display antiinflammatory activity in a rat colitis model.


参考文献

1. Checkley, S.A., et al. 1981. Br J Psychiatry. 138: 248-251. PMID: 6268238

2. Potter, W.Z., et al. 1981. Psychopharmacol Bull. 17: 26-29. PMID: 6453356

3. Zhu, M.Y., et al. 1998. J. Neurochem. 70: 1547-1555. PMID: 9523572

4. Okugawa, G. et al. 1999. J. Neuroendocrinol. 11: 887-895. PMID: 10520140

5. Smith, N.C. and Levi, R. 1999. J. Pharmacol. Exp. Ther. 291: 456-463. PMID: 10525059

6. Zhao, Z., et al. 2008. Neuropsychopharmacology. 33: 3190-3200. PMID: 18418364

7. Bachis, A., et al. 2008. Neurosci. Lett. 442: 104-108. PMID: 18621098

Physical State :
Solid
Solubility :
Soluble in water (>25 mg/ml), alcohol, and methanol.
保存方法 :
Store at room temperature
Melting Point :
214-218° C
IC50 :
Serotonin transporter: IC50 = 2.5 nM
Ki Data :
SLC6A2 : Ki= 4 nM; ST: Ki= 61 nM; DAT: Ki= 78720 nM
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
RTECS :
HO0525000
PubChem CID :
Merck Index :
14: 2920
MDL Number :
MFCD00058108
EC Number :
200-373-1
SMILES :
CNCCCN1C2=CC=CC=C2CCC3=CC=CC=C31.Cl

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Desipramine hydrochloride (CAS 58-28-6)  参考文献

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引用 1 to 5 of 5 合計

PMID: # 29030399  2018. FASEB J. 32: 782-794.

PMID: # 28587819  Benham, RS. et al. 2017. Behav. Brain Res. 332: 172-179.

PMID: # 27080063  Reimets, R. et al. 2016. Behavioural brain research. 308: 53-63.

PMID: # 26100518  Lin, PH. et al. 2015. J. Biomed. Sci. 22: 44.

PMID: # 26449523  Toxicology. 17-29.

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