Clopamide CAS: 636-54-4
MF: C14H20ClN3O3S
MW: 345.84
A compound that selectively inhibit the sodium chloride cotransporter.

Clopamide (CAS 636-54-4)

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別名: 4-chloro-N-(2,6-dimethyl-1-piperidyl)-3-sulfamoyl-benzamide
アプリケーション: Clopamide is a compound that selectively inhibit the sodium chloride cotransporter
CAS 番号: 636-54-4
Purity: ≥98%
Molecular Weight: 345.84
Molecular Formula: C14H20ClN3O3S
補足情報: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
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* Refer to Certificate of Analysis for lot specific data (including water content).

Clopamide is shown to selectively inhibit the NCCT (sodium chloride cotransporter). After Hypokalemia was more marked with chronic administration to hypertension patients. Reported to considerably elevate the mean blood glucosein diabetic patients not receiving insulin. Also reported to lower body weight and blood pressure, and raise blood urea in diabetic patients.


参考文献

1. McNeil, J.J., et al. 1987. Clin. Pharmacol. Ther. 42: 299-304. PMID: 3621784
2. Hicks, B.H., et al. 1973. Metab. Clin. Exp. 22: 101-109. PMID: 4567002

Physical State :
Solid
Solubility :
Soluble in DMSO (20 mg/mL), ethanol (5 mg/mL warm), and water (partly miscible).
保存方法 :
Store at room temperature
Melting Point :
248-249° C
Refractive Index :
n20D 1.61 (Predicted)
pK Values :
pKa: 9.41, pKb: 3.59
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
PubChem CID :
Merck Index :
14: 2393
MDL Number :
MFCD00941495
EC Number :
211-261-7
SMILES :
C[[email protected]@H]1CCC[[email protected]@H](N1NC(=O)C2=CC(=C(C=C2)Cl)S(=O)(=O)N)C

Download SDS (MSDS)

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