Clomipramine hydrochloride CAS: 17321-77-6
MF: C19H23ClN2•HCl
MW: 351.32
A selective ST, SLC6A2, and DAT inhibitor.

Clomipramine hydrochloride (CAS 17321-77-6)

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Clomipramine hydrochloride is rated 5.0 out of 5 by 1.
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別名: Anafranil hydrochloride
アプリケーション: Clomipramine hydrochloride is a selective ST, SLC6A2, and DAT inhibitor
CAS 番号: 17321-77-6
Purity: ≥98%
Molecular Weight: 351.32
Molecular Formula: C19H23ClN2•HCl
補足情報: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
* Refer to Certificate of Analysis for lot specific data (including water content).
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Clomipramine hydrochloride (Anafranil) is a hydrochloride salt of clomipramine which is an ST (serotonin transporter/SERT), SLC6A2 (norepinephrine transporter/NET), and DAT (dopamine transporter) blocker with Ki of 0.14, 54 and 3 nM, respectively. Clomipramine hydrochloride is a tricyclic antidepressant, a norepinephrine-reuptake inhibitor, and an antiobsessional drug.

Clomipramine hydrochloride is an inhibitor of D2 receptor (Ki = 162 nM), D3 receptor (Ki = 30 nM), AR (α1-adrenergic receptor, Ki = 3.2 nM), α2-adrenergic receptor (Ki = 525 nM), H1 receptor (Ki = 31 nM), mACh receptors (Ki = 37 nM), 5-HT2A receptor (Ki = 36 nM), 5-HT2C receptor (Ki = 65 nM), 5-HT3 receptor (Ki = 85 nM), 5-HT6 receptor (Ki = 54 nM), 5-HT7 receptor (Ki = 127 nM), D1 receptor (Ki = 219 nM).


参考文献

1. McTavish, D. and Benfield, P. 1990. Drugs. 39: 136-153. PMID: 2178909
2. Ortiz, J. and Artigas, F. 1992. Br. J. Pharmacol. 105: 941-946. PMID: 1387022
3. Owens, M.J., et al. 1997. J. Pharmacol. Exp. Ther. 283: 1305-1322. PMID: 9400006

Physical State :
Solid
Solubility :
Soluble in water (125 mg/ml), ethanol (70 mg/ml at 25° C), chloroform (1:3), DMSO (70 mg/ml at 25° C), and dilute aqueous acid.
保存方法 :
Store at room temperature
Melting Point :
189-192° C
Refractive Index :
n20D 1.58 (Predicted)
IC50 :
Plasmodium falciparum: IC50 = 5.01 µM; Mitochondrial import inner membrane translocase subunit TIM10: IC50 = 37.8 µM (Saccharomyces cerevisiae S288c)
Ki Data :
ST: Ki= 0.14 nM; DAT: Ki= 3 nM; α1-adrenergic receptor : Ki= 3.2 nM; H1 receptor: Ki= 31 nM; 5-HT2A receptor: Ki= 36 nM; SLC6A2: Ki= 54 nM
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
RTECS :
HN9055000
PubChem CID :
Merck Index :
14: 2387
MDL Number :
MFCD00069234
EC Number :
241-344-3
SMILES :
CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl.Cl

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Clomipramine hydrochloride (CAS 17321-77-6)  参考文献

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引用 1 to 2 of 2 合計

PMID: # 27681341  Alves, V. et al. 2017. J Anal Toxicol. 41: 45-53.

PMID: # 26189207  Alves, V. et al. 2015. Journal of chromatography. A. 1408: 30-40.

引用 1 to 2 of 2 合計
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