Cinnamycin CAS: 110655-58-8
MF: C89H125N25O25S3
MW: 2041.29
A tricyclic antibiotic produced by several species of Streptoverticillium..

Cinnamycin (CAS 110655-58-8)

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別名: Lanthiopeptin; Ro 09-0198
アプリケーション: Cinnamycin is a tricyclic antibiotic produced by several species of Streptoverticillium.
CAS 番号: 110655-58-8
Molecular Weight: 2041.29
Molecular Formula: C89H125N25O25S3
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* Refer to Certificate of Analysis for lot specific data (including water content).
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Cinnamycin (lanthiopeptin) is a high molecular weight tricyclic antibiotic produced by several species of Streptoverticillium. Cinnamycin is a potent indirect inhibitor of PLA2 (phospholipase A2), acting by specifically sequestering phosphatidylethanolamine (PE), a major component of the mammalian plasma cell membrane. Cinnamycin induces trans-bilayer phospholipid movement in cell membranes to expose internally bound PE. At high surface concentrations of PE, cinnamycin induces membrane re-organization including membrane fusion and alteration of gross morphology.

Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in DMSO (10 mg/ml), DMF, methanol, ethanol, and water (poorly).
保存方法 :
Store at -20° C
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
RTECS :
GE1745000
PubChem CID :
MDL Number :
MFCD01770867
SMILES :
C[[email protected]@H]1C2C(=O)N[[email protected]@H](CCCCNC[[email protected]]3C(=O)N[[email protected]](C(=O)NCC(=O)N4CCC[[email protected]]4C(=O)N[[email protected]](C(=O)N[[email protected]]5C(SC[[email protected]@H](C(=O)N3)NC(=O)[[email protected]](CSC[[email protected]@H](C(=O)N[[email protected]](C(=O)NCC(=O)N[[email protected]](C(=O)N2)CC(=O)N)[[email protected]](C(=O)O)O)NC(=O)[[email protected]@H](NC(=O)[[email protected]@H](NC5=O)CC6=CC=CC=C6)C(C)C)NC(=O)[[email protected]@H](NC(=O)[[email protected]@H](NC(=O)[[email protected]](CS1)N)CCCNC(=N)N)CCC(=O)N)C)CC7=CC=CC=C7)CC8=CC=CC=C8)C(=O)O

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Cinnamycin (CAS 110655-58-8)  参考文献

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PMID: # 29930080  Stewart, SE. et al. 2018. J. Cell. Sci. 131:

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