CDP 840 hydrochloride CAS: 162542-90-7
MF: C25H27NO2.HCl
MW: 409.95
A selective and potent inhibitor of PDE 4.

CDP 840 hydrochloride (CAS 162542-90-7)

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別名: 4-(2-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-phenylethyl)pyridine
アプリケーション: CDP 840 hydrochloride is a selective and potent inhibitor of PDE 4
CAS 番号: 162542-90-7
Molecular Weight: 409.95
Molecular Formula: C25H27NO2.HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

CDP 840 hydrochloride is a potent and selective inhibitor of phosphodiesterase 4 (PDE4) (IC50 = 12 nM). This compound competitively inhibits all PDE4 isoenzymes, which in turn prevents the cleavage of phosphodiester bonds found in secondary messenger molecules. This prolongs signal transduction and any subsequent effects.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
保存方法 :
Desiccate at room temperature
Refractive Index :
n20D 1.59 (Predicted)
Optical Activity :
α20/D +39°, c = 0.48 in ethanol
IC50 :
TNFalpha release: IC50 = 0.67 nM (human whole blood); Phosphodiesterase 4A: IC50 = 2.1 nM (human); Phosphodiesterase 4B: IC50 = 1.4 nM (human); Phosphodiesterase 4C: IC50 = 4.5 nM (human); Phosphodiesterase 4D: IC50 = 2.1 nM (human)
Ki Data :
Phosphodiesterase 4A: Ki= 4 nM (human); Phosphodiesterase 4B: Ki= 60 nM (human); Phosphodiesterase 4C: Ki= 60 nM (human); Phosphodiesterase 4D: Ki= 60 nM (human); [3H]rolipram displacement from PDE4 by RBA: Ki= 16 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
US7546100
PubChem CID :
9885877
SMILES :
COC1=C(C=C(C=C1)C(CC2=CC=NC=C2)C3=CC=CC=C3)OC4CCCC4

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