caspase-11抗体(17D9): sc-56038

caspase-11 Antibody (17D9) is a high quality monoclonal caspase-11 antibody (also designated Caspase 11 antibody, Caspase 4 antibody, CASP-11 antibody or CASP-4 antibody) suitable for the detection of the caspase-11 protein of mouse and rat origin. caspase-11 Antibody (17D9) is available as the non-conjugated anti-caspase-11 antibody. Caspase-11 plays a crucial role in OLG death and pathogenesis in experimental autoimmune encephalomyelitis (EAE). Caspase-11 also leads to the synthesis of the functional form of the cytokine interleukin-1beta. Caspases are a family of mammalian proteases related to the ced-3 gene of Caenorhabditis elegans. These ced-3 orthologs mediate many of the morphological and biochemical features of apoptosis, including structural dismantling of cell bodies and nuclei, fragmentation of genomic DNA, destruction of regulatory proteins, and propagation of other pro-apoptotic molecules. Based on their substrate specificities and DNA sequence homologies, the 14 currently identified caspases may be divided into three groups: apoptotic initiators, apoptotic executioners and inflammatory mediators. Upon activation, caspases appear to play an important role in sequelae of traumatic brain injury, spinal cord injury and cerebral iischemia. In addition, they may also play a role in mediating cell death in chronic neurodegenerative conditions such as Alzheimer′s disease, Huntington′s disease and amyotrophic lateral sclerosis.