Caspase-1 Inhibitor II Caspase-1 Inhibitor II is an inhibitor of caspase-1, caspase-4, and caspase-5.

Caspase-1 Inhibitor II (CAS 178603-78-6)

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別名: Ac-YVAD-CMK
アプリケーション: Caspase-1 Inhibitor II is an inhibitor of caspase-1, caspase-4, and caspase-5
CAS 番号: 178603-78-6
Molecular Weight: 540.99
Molecular Formula: C24H33ClN4O8
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
* Refer to Certificate of Analysis for lot specific data (including water content).
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Caspase-1 Inhibitor II (Ac-YVAD-CMK) is a cell-permeable and irreversible inhibitor of caspase-1 (Ki = 760 pM), caspase-4, and caspase-5. It also inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Caspase-1, originally designated ICE (for IL-1 converting enzyme), is a member of the group of caspases with large prodomains. Active caspase-1, a (p20/p10)2 tetramer, is necessary and sufficient for cleavage of precursor IL-1 as well as for induction of apoptosis in some cell lines. Following use of the inhibitor, standard apoptosis assays can be used to examine treated cells for evidence of apoptosis.
Additional caspase-1 inhibitors available:
caspase-1 inhibitor (sc-3069)
caspase-1 inhibitor VI (sc-3071)
Caspase-1 Inhibitor IV (sc-300324)
Caspase-1 Inhibitor I (sc-358878)


参考文献

1. Brenner, B., et al. 1998. Cell Death Differ. 5: 29-37. PMID: 10200443

2. Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273: 32608-32613. PMID: 9829999

3. Hilbi, H., et al. 1998. J. Biol. Chem. 273: 32895-32900. PMID: 9830039

4. Thornberry, N.A., et al. 1998. Science. 281: 1312-1316. PMID: 9721091

5. Schlegel, J., et al. 1996. J. Biol. Chem. 271: 1841-1844. PMID: 8567626

6. Enari, M., et al. 1995. Nature. 375: 78-81. PMID: 7536900

7. Walker, N.P., et al. 1994. Cell. 78: 343-352. PMID: 8044845

8. Thornberry, N.A., et al. 1992. Nature. 356: 768-774. PMID: 1574116

9. Wu, Bihua., et al., 2010. Ac-YVAD-CMK Decreases Blood-Brain Barrier Degradation by Inhibiting Caspase-1 Activation of Interleukin-1β in Intracerebral Hemorrhage Mouse Model. Translational stroke research. 1(1): 57-64. PMID: 20596246

用法 :
Stable for up to 1 year after receipt when stored at -20°C. Stock solutions should be aliquoted and stored at -20°C for up to 1 month. Protect from light, moisture sensitive.
Physical State :
Solid
Sequence :
Ac-Tyr-Val-Ala-Asp-CMK
Solubility :
Soluble in DMSO (~20 mg/ml), water (0.25 mg/ml at 25° C), PBS pH7.2 (~0.25 mg/ml), and DMF (~10 mg/ml).
保存方法 :
Store at -20° C
Boiling Point :
969.07° C at 760 mmHg (Predicted)
Density :
1.31 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
Ki Data :
caspase-1: Ki= 760 pM
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
RTECS :
AY3079566
PubChem CID :
MDL Number :
MFCD00237124
SMILES :
C[[email protected]@H](C(=O)N[[email protected]@H](CC(=O)O)C(=O)CCl)NC(=O)[[email protected]](C(C)C)NC(=O)[[email protected]](CC1=CC=C(C=C1)O)NC(=O)C

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Caspase-1 Inhibitor II (CAS 178603-78-6)  参考文献

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引用 1 to 6 of 6 合計

PMID: # 34092246  Wu, Y.|He, F.|Zhang, C.|Zhang, Q.|Su, X.|Zhu, X.|Liu, A.|Shi, W.|Lin, W.|Jin, Z.|Yang, H.|Lin, J.| et al. 2021. J Nanobiotechnology. 19: 170.

PMID: # 31085177  Segovia, M.|Russo, S.|Jeldres, M.|Mahmoud, YD.|Perez, V.|Duhalde, M.|Charnet, P.|Rousset, M.|Victoria, S.|Veigas, F.|Louvet, C.|Vanhove, B.|Floto, RA.|Anegon, I.|Cuturi, MC.|Girotti, MR.|Rabinovich, GA.|Hill, M.| et al. 2019. Cancer Cell. 35: 767-781.e6.

PMID: # 29361084  Fuke, N. et al. 2018. Inflamm. Bowel Dis. 24: 317-331.

PMID: # 31455532  Meth. Enzymol. 287-298.

PMID: # 31767863  Cell Death Dis. 10: 882.

PMID: # 31597705  J. Immunol. 203: 2712-2723.

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