Carbachol CAS: 51-83-2
Carbachol is an inhibitor of TNF-α and of neuronal apoptosis.

Carbachol (CAS 51-83-2)

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別名: Carbamoylcholine chloride; (2-Carbamoyloxyethyl)trimethylammonium chloride
アプリケーション: Carbachol is an inhibitor of TNF-α and of neuronal apoptosis
CAS 番号: 51-83-2
Purity: ≥98%
Molecular Weight: 182.65
Molecular Formula: C6H15N2O2•Cl
補足情報: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
* Refer to Certificate of Analysis for lot specific data (including water content).
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Carbachol is shown to be a non-selective muscarinic cholinergic receptor (mAChR M) and AChR agonist that causes inhibition of apoptosis in cultured rat cerebellar granule neurons. The anti-apoptotic effects of this compound can be completely blocked by 4-diphenylacetoxyl-N methylpiperidine methiodide. Additionally, this agent has been demonstrated to prevent an increase in endothelial cell permeability induced by TNF-α and also cause a decrease in phosphor-ERK1/2 and phosphor-JNK 1.


参考文献

1. Yan, G.M., et al. 1995. Mol. Pharmacol. 47: 248-257. PMID: 7870032

2. Yamada, T., et al. 1997. Jpn. J. Pharmacol. 73: 311-316. PMID: 9165367

3. Lin, A.L., et al. 2008. Am. J. Physiol., Cell Physiol. 294: C1454-C1464. PMID: 18385290

4. Xu, D.Y., et al. 2008. Life Sci. 82: 1083-1091. PMID: 18440028

5. Li, Y.Z., et al. 2010. Acta Pharmacol Sin. [Epub ahead of print]. PMID: 20871620

Physical State :
Solid
Solubility :
Soluble in water (1 g/ml), ethanol (20 mg/ml), methanol (100 mg/ml), and DMSO (50 mM). Insoluble in acetone, chloroform, and ether.
保存方法 :
Desiccate at room temperature
Melting Point :
210° C (dec.)
IC50 :
Muscarinic acetylcholine receptor: IC50 = 6.7 nM (Rattus norvegicus); Muscarinic acetylcholine receptor M2: IC50 = 34 nM (Rattus norvegicus); Muscarinic acetylcholine receptor M3: IC50 = 5.5 µM (Rattus norvegicus); Muscarinic acetylcholine receptor M2: IC50 = 3.8 nM (human); Muscarinic acetylcholine receptor M3: IC50 = 0.88 µM (human); Muscarinic acetylcholine receptor M2: EC5050 = 0.7 µM (human); Muscarinic acetylcholine receptor M1: EC5050 = 3.81 µM (human); Aorta: EC5050 = 0.51 µM (Rattus norvegicus)
Ki Data :
Muscarinic acetylcholine receptor: Ki= 9 nM (Rattus norvegicus); Muscarinic acetylcholine receptor M1: Ki= 19.9 nM (Mus musculus); Muscarinic acetylcholine receptor M1: Ki= 31 nM (Rattus norvegicus); Muscarinic acetylcholine receptor M4: Ki= 24 nM (human)
pK Values :
pKa: 12.54
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
RTECS :
GA0875000
PubChem CID :
Merck Index :
14: 1779
MDL Number :
MFCD00012011
EC Number :
200-127-3
Beilstein Registry :
3917459
SMILES :
C[N+](C)(C)CCOC(=O)N.[Cl-]

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Carbachol (CAS 51-83-2)  参考文献

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引用 1 to 10 of 10 合計

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PMID: # 25269881  Lau, CG. et al. 2014. Mol. Reprod. Dev. 81: 994-1008.

PMID: # 9668091  Murga, C. et al. 1998. J. Biol. Chem. 273: 19080-19085.

PMID: # 9770463  Ma , Y.C. et al. 1998. Proc. Natl. Acad. Sci. USA. 95: 12197-12201.

PMID: # 32268182  Mol. Biochem. Parasitol. 111276.

PMID: # 32425158  Elife. 9:

PMID: # 31453231  J Biol Methods. 4: e74.

PMID: # 32878247  Int J Mol Sci.

PMID: # 30710269  Methods Mol Biol. 95-109.

引用 1 to 10 of 10 合計
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