Apelin-13 CAS: 217082-58-1
MF: C69H111N23O16S
MW: 1550.83

Apelin-13 (CAS 217082-58-1)

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別名: Apelin-13 is also known as Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe.
アプリケーション: Apelin-13 is a 13-amino acid polypeptide and endogenous ligand of the G-protein coupled receptor APJ.
CAS 番号: 217082-58-1
Purity: ≥95%
Molecular Weight: 1550.83
Molecular Formula: C69H111N23O16S
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* Refer to Certificate of Analysis for lot specific data (including water content).
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Apelin-13 is a 13 amino acid polypeptide encoded by the apelin gene which yields a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids (apelin-36, apelin-17, and apelin-13, respectively). Apelin-13 is an endogenous ligand of the APJ receptor, a G protein-coupled receptor (EC50 = 370 μM), that plays important roles in regulating fluid homeostasis, cardiovascular function, and insulin sensitivity. Research has also shown that Apelin-36 blocks the entry of human immunodeficiency virus into cells. However, unlike apelin-36, Apelin-13 is a poor blocker of HIV cell entry.


参考文献

1. Tatemoto, K. et al. 1998. Biochem. Biophys. Res. Commun. 251(2): 471-476. PMID: 9792798
2. Habata, Y. et al. 1999. Biochim. Biophys. Acta. 1452(1): 25-35. PMID: 10525157
3. Zou, M.X. et al. 2000. FEBS Lett. 473(1): 15-18. PMID: 10802050
4. Lee, D.K. et al. 2000. J. Neurochem. 74(1): 34-41. PMID: 10617103
5. Kleinz, M.J. and Davenport, A.P. 2005. Pharmacol. Ther. 107(2): 198-211. PMID: 15907343

Appearance :
Crystalline
Physical State :
Solid
Sequence :
GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE
Solubility :
Soluble in PBS (pH 7.2) (~10 mg/ml), ethanol (~20 mg/ml), DMSO (~30 mg/ml), and DMF (~30 mg/ml).
保存方法 :
Store at -20° C
Density :
1.5±0.1 g/cm3
Refractive Index :
n20D 1.69 (Predicted)
IC50 :
G protein-coupled receptor : EC5050 = 0.37 nM
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD02094627
SMILES :
CC(C)C[[email protected]@H](C(=O)N[[email protected]@H](CO)C(=O)N[[email protected]@H](CC1=CN=CN1)C(=O)N[[email protected]@H](CCCCN)C(=O)NCC(=O)N2CCC[[email protected]]2C(=O)N[[email protected]@H](CCSC)C(=O)N3CCC[[email protected]]3C(=O)N[[email protected]@H](CC4=CC=CC=C4)C(=O)O)NC(=O)[[email protected]](CCCN=C(N)N)NC(=O)[[email protected]@H]5CCCN5C(=O)[[email protected]](CCCN=C(N)N)NC(=O)[[email protected]](CCC(=O)N)N

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Apelin-13 (CAS 217082-58-1)  参考文献

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引用 1 to 10 of 16 合計

PMID: # 32538173  Sabry, MM.|Ahmed, MM.|Maksoud, OMA.|Rashed, L.|Morcos, MA.|El-Maaty, AA.|Maher Galal, A.|Sharawy, N.| et al. 2020. Arch Physiol Biochem. 1-10.

PMID: # 31385138  Foroughi, K.|Khaksari, M.|Rahmati, M.|Bitaraf, FS.|Shayannia, A.| et al. 2019. Neurochem. Res.

PMID: # 30709405  Duan, J.|Cui, J.|Yang, Z.|Guo, C.|Cao, J.|Xi, M.|Weng, Y.|Yin, Y.|Wang, Y.|Wei, G.|Qiao, B.|Wen, A.| et al. 2019. J Neuroinflammation. 16: 24.

PMID: # 28012561  Bülbül, M.|Sinen, O.|Birsen, İ.|Izgüt-Uysal, V.| et al. 2017. Neuropeptides. 63: 91-97.

PMID: # 26924778  Zhang, NK. et al. 2016. Cell Transplant. 25: 1645-1652.

PMID: # 28627589  Maugeri, G. et al. 2016. J. Cell. Physiol. 29: 25-35.

PMID: # 26893689  Huang, Q. et al. 2016. Oncol Lett. 11: 1051-1056.

PMID: # 26631263  Yang, Y. et al. 2016. Peptides. 75: 96-100.

PMID: # 27630697  Bao, HJ. et al. 2016. Neural Regen Res. 11: 1128-33.

PMID: # 27343409  Bao, H. et al. 2016. Neurosci. Lett. 628: 219-24.

引用 1 to 10 of 16 合計
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