A 205804 CAS: 251992-66-2
MF: C15H12N2OS2
MW: 300.39
A selective inhibitor of E-selectin and ICAM-1 expression.

A 205804 (CAS 251992-66-2)

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A 205804 is rated 5.0 out of 5 by 1.
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別名: 4-(p-tolylthio)thieno[2,3-c]pyridine-2-carboxamide
アプリケーション: A 205804 is a selective inhibitor of E-selectin and ICAM-1 expression
CAS 番号: 251992-66-2
Purity: ≥98%
Molecular Weight: 300.39
Molecular Formula: C15H12N2OS2
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* Refer to Certificate of Analysis for lot specific data (including water content).
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A 205804 is a selective inhibitor of E-selectin and ICAM-1 expression (IC50 values are 20, 25 and > 1000 nM for TNF-α-induced E-selectin, ICAM-1 and VCAM-1 expression respectively). Effective inhibitor of cell-cell adhesion in an in vitro flow experiment.


参考文献

1. Stewart, A.O., et al. 2001. J. Med. Chem. 44: 988-1002. PMID: 11300880
2. Zhu, G.D., et al. 2001. J. Med. Chem. 44: 3469-3487. PMID: 11585452
3. Zhu, G.D., et al. 2002. J. Org. Chem. 67: 943-948. PMID: 11856042

Physical State :
Solid
Solubility :
Soluble in DMSO (60 mg/ml at 25° C), water (<1 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
保存方法 :
Store at 4° C
Melting Point :
216.81° C (Predicted)
Boiling Point :
~581.3° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.74 (Predicted)
IC50 :
E-selectin: IC50 = 20 nM; ICAM-1: IC50 = 25 nM
pK Values :
pKb: 2.26 (Predicted)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
RTECS :
XJ9088360
PubChem CID :
MDL Number :
MFCD09038566
SMILES :
CC1=CC=C(C=C1)SC2=C3C=C(SC3=CN=C2)C(=O)N

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