A 205804 (CAS 251992-66-2)
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別名:
4-(p-tolylthio)thieno[2,3-c]pyridine-2-carboxamide
アプリケーション：
A 205804 is a selective inhibitor of E-selectin and ICAM-1 expression
CAS 番号:
251992-66-2
Purity:
≥98%
Molecular Weight:
300.39
Molecular Formula:
C15H12N2OS2
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
A 205804 is a selective inhibitor of E-selectin and ICAM-1 expression (IC50 values are 20, 25 and > 1000 nM for TNF-α-induced E-selectin, ICAM-1 and VCAM-1 expression respectively). Effective inhibitor of cell-cell adhesion in an in vitro flow experiment.
参考文献
1. Stewart, A.O., et al. 2001. J. Med. Chem. 44: 988-1002. PMID: 11300880
2. Zhu, G.D., et al. 2001. J. Med. Chem. 44: 3469-3487. PMID: 11585452
3. Zhu, G.D., et al. 2002. J. Org. Chem. 67: 943-948. PMID: 11856042
Physical State
:
Solid
Solubility
:
Soluble in DMSO (60 mg/ml at 25° C), water (<1 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
保存方法
:
Store at 4° C
Melting Point
:
216.81° C (Predicted)
Boiling Point
:
~581.3° C at 760 mmHg (Predicted)
Density
:
~1.4 g/cm3 (Predicted)
Refractive Index
:
n20D 1.74 (Predicted)
IC50
:
E-selectin: IC50 = 20 nM; ICAM-1: IC50 = 25 nM
pK Values
:
pKb: 2.26 (Predicted)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
RTECS
:
XJ9088360
PubChem CID
:
MDL Number
:
MFCD09038566
SMILES
:
CC1=CC=C(C=C1)SC2=C3C=C(SC3=CN=C2)C(=O)N
Download SDS (MSDS)
分析表
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