Zofenoprilat-d5 CAS: 1217716-12-5
MF: C15H14D5NO3S2
MW: 330.48
An active metabolite of Zofenopril.

Zofenoprilat-d5 (CAS 1217716-12-5)

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Nomi alternativi: (4S)-1-[(2S)-3-Mercapto-2-methyl-1-oxopropyl]-4-(phenyl-d5-thio)-L-proline
Applicazione: Zofenoprilat-d5 is an active metabolite of Zofenopril
Numero CAS: 1217716-12-5
Peso molecolare: 330.48
Formula molecolare: C15H14D5NO3S2
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
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Zofenoprilat-d5 is an active metabolite of Zofenopril. Zenopril is an antioxidant that acts as an angiotensin-converting enzyme inhibitor. Studies indicate that Zenopril increases the calcium cycling of sarcoplasmic reticulum and enhances active calcium uptake into the sarcoplasmic reticulum. The compounds Zenopril and Captopril are suggested to be the only ACE inhibitors that structurally have sulphydryl groups (SH). Zenopril has been reported to to convert into Zofeniprilate, the active free sulfhydryl compound, after metabolic hydrolysis. Additional Zofenopril metabolites include: Zofenopril Acyl-β-D-glucuronide (sc-220407)


Referenze

1. Dal Bo, L., et al. 2000. J. Chromatogr. B Biomed. Sci. Appl. 749: 287-294. PMID: 11145066
2. Borghi, C., et al. 2004. Expert Opin Pharmacother. 5: 1965-1977. PMID: 15330734
3. Kalender, A.M., et al. 2009. J Brachial Plex Peripher Nerve Inj. 4: 6. PMID: 19508704
4. Frascarelli, S., et al. 2009. J. Cardiovasc. Pharmacol. 54: 456-463. PMID: 19738489
5. Cialdai, C., et al. 2010. Naunyn Schmiedebergs Arch. Pharmacol. 382: 455-461. PMID: 20848272

Stato fisico :
Solid
CONSERVAZIONE :
Store at -20° C
Punto di scioglimento :
60-62°C (lit.)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
PubChem CID :
SMILES :
[2H]C1=C(C(=C(C(=C1[2H])[2H])S[[email protected]]2C[[email protected]](N(C2)C(=O)[[email protected]](C)CS)C(=O)O)[2H])[2H]

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