Z-VDVAD-FMK MF: C32H46FN5O11
MW: 695.73
An irreversible inhibitor of Caspase-2.

Z-VDVAD-FMK

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Z-VDVAD-FMK is rated 5.0 out of 5 by 1.
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Nomi alternativi: Benzyloxycarbonyl-Val-Asp(OMe)-Val-Ala-Asp(OMe)-fluoromethylketone
Applicazione: Z-VDVAD-FMK is an irreversible inhibitor of Caspase-2
Peso molecolare: 695.73
Formula molecolare: C32H46FN5O11
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
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Z-VDVAD-FMK (Caspase-2 inhibitor) is a cell-permeable, irreversible inhibitor of caspase-2. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. In a study of 7-ketocholesterol (sc-210630)-induced cell death and the association with polar lipid accumulation, the effects of Z-VDVAD-FMK on the lipid profile was evaluated by staining with Nile Red (sc-203747). Z-VDVAD-FMK has also been shown to inhibit programmed macrophage cell death induced by Brucella species gram-negative bacteria.

Purity: Single spot by TLC.


Referenze

1. Vejux, A. et al. 2007. Cytometry A. 71(8): 550-562. PMID: 17458884
2. Chen, F. and He, Y. 2009. PLoS ONE. 4(8): e6830. PMID: 19714247

Utilizzo :
Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C.
Aspetto :
Powder
Stato fisico :
Solid
Solubilità :
Soluble in DMSO (13.91 mg/ml), and DMSO/DMF (20 mM).
CONSERVAZIONE :
Store at -20° C
Punto di ebollizione :
980.10° C at 760 mmHg (Predicted)
Densità :
1.23 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.51 (Predicted)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
PubChem CID :
Numero MDL :
MFCD03452881
SMILES :
C[[email protected]@H](C(=O)N[[email protected]@H](CC(=O)OC)C(=O)CF)NC(=O)[[email protected]](C(C)C)NC(=O)[[email protected]](CC(=O)OC)NC(=O)[[email protected]](C(C)C)NC(=O)OCC1=CC=CC=C1

Download SDS (MSDS)

CERTIFICATO DI ANALISI

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Z-VDVAD-FMK  Citazioni prodotti

Vedi quanti altri hanno usato Z-VDVAD-FMK. Clicca sulla voce per laccesso a PubMed .

Ciatazioni 1 a4 di 4 totali

PMID: # 24204395  Wu, CC. et al. 2013. Evidence-based complementary and alternative medicine : eCAM. 2013: 548929.

PMID: # 19118032  Trougakos, IP. et al. 2009. Clin. Cancer Res. 15: 48-59.

PMID: # 19154411  Lee, JC. et al. 2009. Cancer science. 100: 503-13.

PMID: # 17082817  Hanoux, V. et al. 2007. Cell Death Differ. 14: 671-81.

Ciatazioni 1 a4 di 4 totali
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