Z-FA-FMK CAS: 197855-65-5
MF: C21H23FN2O4
MW: 386.42
Inhibits effector, but not initator caspases in vitro, and suppress some forms of apoptosis.

Z-FA-FMK (CAS 197855-65-5)

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Nomi alternativi: Z-Phe-Ala fluoromethyl ketone
Applicazione: Z-FA-FMK is inhibits effector, but not initator caspases in vitro, and suppress some forms of apoptosis
Numero CAS: 197855-65-5
Purezza: ≥95%
Peso molecolare: 386.42
Formula molecolare: C21H23FN2O4
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
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Z-FA-FMK is an irreversible inhibitor of cysteine proteases, such as cathepsin B, L, and S, that do not require a P1 Asp residue. The compound has also inhibitited papain and cruzain. Z-FA-FMK has been shown to selectively inhibit effector caspase-2, caspase-3, caspase-6, and caspase-7 without affecting initiator caspase-8 and caspase-10 while showing minimal toxicity to normal mammalian cells in vitro. Due to Z-FA-FMK's effector caspase specificity, the compound has been recorded to inhibit some forms of caspase mediated apoptosis. The compound has been observed to be an effective in time dependent inactivation of cathepsin B isozymes from a number of tissues. Studies show Cathepsin B-like activity plays a role in the cascade of proteolytic cartilage destruction. Z-FA-FMK is an inhibitor of cathepsin H.


Referenze

1. Shaw, E., et al. 1981. Meth. Enzymol. 80: 820-826. PMID: 7043207
2. Smith, R.E., et al. 1988. Anticancer Res. 8: 525-529. PMID: 3178145
3. Van Noorden, C.J., et al. 1988. J. Rheumatol. 15: 1525-1535. PMID: 3204599
4. Brömme, D., et al. 1989. Biochem. J. 264: 475-481. PMID: 2604727
5. Ahmed, N.K., et al. 1992. Biochem. Pharmacol. 44: 1201-1207. PMID: 1417942
6. Harth, G., et al. 1993. Mol. Biochem. Parasitol. 58: 17-24. PMID: 8459830
7. McGrath, M.E., et al. 1995. J. Mol. Biol. 247: 251-259. PMID: 7707373
8. Lotem, J., et al. 1996. Proc. Natl. Acad. Sci. U.S.A. 93: 12507-12512. PMID: 8901612
9. Eichhold, T.H., et al. 1997. J Pharm Biomed Anal. 16: 459-467. PMID: 9589405
10. Schotte, P., et al. 2001. J. Biol. Chem. 276: 21153-21157. PMID: 11290751
11. Guo, M., et al. 2002. J. Biol. Chem. 277: 14829-14837. PMID: 11815600
12. Lopez-Hernandez, F.J., et al. 2003. Mol. Cancer Ther. 2: 255-263. PMID: 12657720

Stato fisico :
Solid
Solubilità :
Soluble in DMSO (10 mM).
CONSERVAZIONE :
Store at -20° C
Punto di scioglimento :
~226.14° C (Predicted)
Punto di ebollizione :
630.54° C at 760 mmHg
Densità :
1.21 g/cm3
Indice di rifrazione :
n20D 1.55
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
PubChem CID :
Numero MDL :
MFCD00883668
SMILES :
CC(C(=O)CF)NC(=O)C(CC1=CC=CC=C1)NC(=O)OCC2=CC=CC=C2

Download SDS (MSDS)

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Z-FA-FMK (CAS 197855-65-5)  Citazioni prodotti

Vedi quanti altri hanno usato Z-FA-FMK (CAS 197855-65-5). Clicca sulla voce per laccesso a PubMed .

Ciatazioni 1 a10 di 15 totali

PMID: # 30720418  Fuller, J.|Surtees, RA.|Shaw, AB.|Álvarez-Rodríguez, B.|Slack, GS.|Bell-Sakyi, L.|Mankouri, J.|Edwards, TA.|Hewson, R.|Barr, JN.| et al. 2019. J Gen Virol. 100: 392-402.

PMID: # 26639105  Staines, KA. et al. 2016. J. Cell. Physiol. 231: 1392-404.

PMID: # 27084336  Zhou, Y. et al. 2016. Mol Neurodegener. 11: 28.

PMID: # 28105029  Welsby, I. et al. 2016. Front Immunol. 7: 663.

PMID: # 25092290  Singh, D. et al. 2014. The Journal of biological chemistry. 289: 27614-24.

PMID: # 24085292  Lee, KH. et al. 2013. J. Biol. Chem. 288: 32777-86.

PMID: # 23812099  Sheedy, FJ.|Grebe, A.|Rayner, KJ.|Kalantari, P.|Ramkhelawon, B.|Carpenter, SB.|Becker, CE.|Ediriweera, HN.|Mullick, AE.|Golenbock, DT.|Stuart, LM.|Latz, E.|Fitzgerald, KA.|Moore, KJ.| et al. 2013. Nat Immunol. 14: 812-20.

PMID: # 22865861  Qi, R. et al. 2012. J. Biol. Chem. 287: 32617-29.

PMID: # 18255115  Gorria, M. et al. 2008. Toxicol. Appl. Pharmacol. 228: 212-224.

PMID: # 18567942  Wen, YD.|Sheng, R.|Zhang, LS.|Han, R.|Zhang, X.|Zhang, XD.|Han, F.|Fukunaga, K.|Qin, ZH.| et al. 2008. Autophagy. 4: 762-9.

Ciatazioni 1 a10 di 15 totali
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