Xli 093 CAS: 646066-59-3
MF: C33H26N6O6
MW: 602.60
5 subtype selective benzodiazepine/GABAA receptor antagonist.

Xli 093 (CAS 646066-59-3)

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Nomi alternativi: Bis[8-ethynyl-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid] 1,3-propanediyl ester
Applicazione: Xli 093 is α5 subtype selective benzodiazepine/GABAA receptor antagonist
Numero CAS: 646066-59-3
Peso molecolare: 602.60
Formula molecolare: C33H26N6O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Xli 093 is an α5 subtype selective benzodiazepine/GABAA receptor antagonist. Xli 093 shows Ki = 5 nM at the α5 receptor in Ltk- cell membranes expressing human α5β3γ2 receptors; little or no affinity at other BDZ/ GABAA subtypes; does not trigger chloride currents in any subtype of tested subtypes, up to 1 μM in concentration; dose-dependently and completely inhibits diazepam stimulated currents in α5β3γ2 receptors.


Referenze

Li, X., et al., Synthesis, in vitro affinity and efficacy of a Bis 8-ethynyl-4H-imidazo[1,5a]-[1,4]benzodiazepine analogue, the first bivalent a5 subtype selective BzR/ GABAA antagonist. J. Med. Chem. 46, 5567-5570, (2003)

Aspetto :
Powder
Stato fisico :
Solid
Solubilità :
Soluble in DMSO: ~16 mg/mL: water: insoluble
CONSERVAZIONE :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Download SDS (MSDS)

CERTIFICATO DI ANALISI

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