Voriconazole-d3 CAS: 188416-29-7
MF: C16H11D3F3N5O
MW: 352.33
A labeled Ergosterol Biosynthesis inhibitor.

Voriconazole-d3 (CAS 188416-29-7)

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Nomi alternativi: VRC-d3; Vfend-d3; Voriconazol-d3
Applicazione: A labeled Ergosterol Biosynthesis inhibitor
Numero CAS: 188416-29-7
Purezza: ≥97% Isotopic Purity ≥99%
Peso molecolare: 352.33
Formula molecolare: C16H11D3F3N5O
Informazioni supplementari: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
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Voriconazole-d3 is a labeled form of Voriconazole which is an Ergosterol biosynthesis inhibitor. This monotriazole antifungal agent inhibits the growth of Candida, Cryptococcus, and Aspergillus species. Studies suggest that Voriconazole-d3 can be synthesized by modifying the structure of fluconazole. This antifungal agent functions by inhibiting cytochrome P450 dependent 14-α-sterol demethylase, which is responsible in the biosynthesis of Ergosterol. Furthermore, Voriconazole-d3 inhibits fungal growth, cell wall thinning, and cell membrane degradation.


Referenze

1. Belanger, P., et al. 1997. Antimicrob. Agents Chemother. 41: 1840-1842. PMID: 9257776
2. Marco, F., et al. 1998. Antimicrob. Agents Chemother. 42: 161-163. PMID: 9449278
3. Espinel-Ingroff, A. 1998. J. Clin. Microbiol. 36: 198-202. PMID: 9431946

Stato fisico :
Solid
Solubilità :
Soluble in Methanol
CONSERVAZIONE :
Store at 4° C
Punto di scioglimento :
115-120° C
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
Trasporto :
UN 2811, Class 6.1, Packing group III
PubChem CID :
SMILES :
[2H]C([2H])([2H])[[email protected]@H](C1=NC=NC=C1F)[[email protected]](CN2C=NC=N2)(C3=C(C=C(C=C3)F)F)O

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Voriconazole-d3 (CAS 188416-29-7)  Citazioni prodotti

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Ciatazioni 1 a1 di 1 totali

PMID: # 25999694  Chung, H. et al. 2015. Drug Des Devel Ther. 9: 2609-16.

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