Voriconazole-d3 is a labeled form of Voriconazole which is an Ergosterol biosynthesis inhibitor. This monotriazole antifungal agent inhibits the growth of Candida, Cryptococcus, and Aspergillus species. Studies suggest that Voriconazole-d3 can be synthesized by modifying the structure of fluconazole. This antifungal agent functions by inhibiting cytochrome P450 dependent 14-α-sterol demethylase, which is responsible in the biosynthesis of Ergosterol. Furthermore, Voriconazole-d3 inhibits fungal growth, cell wall thinning, and cell membrane degradation.
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PMID: # 25999694 Chung, H. et al. 2015. Drug Des Devel Ther. 9: 2609-16.