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Vinblastine Sulfate | CAS 143-67-9 | SCBT - Santa Cruz Biotechnology
Vinblastine Sulfate CAS: 143-67-9
MF: C46H58N4O9•H2SO4
MW: 909.05
An anti-mitotic agent which arrests the cell cycle in the G2/M-phase.

Vinblastine Sulfate (CAS 143-67-9)

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Nomi alternativi: VLB; Vincaleukoblastine sulfate salt
Applicazione: Vinblastine Sulfate is an anti-mitotic agent which arrests the cell cycle in the G2/M-phase
Numero CAS: 143-67-9
Purezza: ≥98%
Peso molecolare: 909.05
Formula molecolare: C46H58N4O9•H2SO4
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
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Vinblastine Sulfate is an antineoplastic agent with anti-mitotic properties and immunosuppressive activity. Vinblastine sulfate depolymerizes microtubules by binding tubulin and inducing self-association in spiral aggregates. This reaction that appears to be regulated by the C-terminus of β-Tubulin and is enhanced by GDP and GTP. Vinblastine sulfate has been observed to arrest the cell cycle in the G2/M-phase by blocking mitotic spindle formation. Vinblastine sulfate has also been documented to trigger Raf-1 activation and phosphorylation of Bcl-2 family proteins, to induce p53 expression, and to induce apoptosis in several tumor cell lines. The compound has also acted as a substrate of PGP and CYP3A4.


Referenze

1. Jordan, M.A., et al. 1985. Cancer Res. 45: 2741-2747. PMID: 3986806
2. Himes, R.H. 1991. Pharmacol. Ther. 51: 257-267. PMID: 1784631
3. Tsukidate, K., et al. 1993. Am. J. Pathol. 143: 918-925. PMID: 8362985
4. Panda, D., et al. 1996. J. Biol. Chem. 271: 29807-29812. PMID: 8939919
5. Rai, S.S. and Woolff, J. 1998. J. Biol. Chem. 273: 31131-31137. PMID: 9813016
6. Tashiro, E., et al. 1998. Jpn. J. Cancer Res. 89: 940-946. PMID: 9818030
7. Jordan, A., et al. 1998. Med Res Rev. 18: 259-296. PMID: 9664292
8. Jordan, M.A. and Wilson, L. 1998. Meth. Enzymol. 298: 252-276. PMID: 9751887
9. Rai, S.S., et al. 1998. Proc. Natl. Acad. Sci. U.S.A. 95: 4253-4257. PMID: 9539723
10. Chen, G.K., et al. 2000. Br. J. Cancer. 83: 892-898. PMID: 10970691

Stato fisico :
Solid
Solubilità :
Soluble in water (10 mg/ml), DMSO (50 mg/ml), and methanol.
CONSERVAZIONE :
Store at -20° C
Punto di scioglimento :
267° C (lit.)
Indice di rifrazione :
n20D 1.67
Attività ottica :
α21/D -21.7°, c = 2 in methanol
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
RTECS :
YY8400000
PubChem CID :
Indice Merck :
14: 9982
Numero MDL :
MFCD00082457
Numero EC :
205-606-0
Registro Beilstein :
3659812
SMILES :
CC[[email protected]@]1(C[[email protected]@H]2C[[email protected]@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[[email protected]]78CCN9[[email protected]]7[[email protected]@](C=CC9)([[email protected]]([[email protected]@]([[email protected]@H]8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O

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Vinblastine Sulfate (CAS 143-67-9)  Citazioni prodotti

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Ciatazioni 1 a9 di 9 totali

PMID: 24667756 | Study of the stability of 26 cytostatic drugs and metabolites in wastewater under different conditions. | Negreira, N. et al. 2014. The Science of the total environment. 482-483: 389-98.

PMID: 24248406 | Lectin levels in tissues of cultured immature wheat embryos | Negreira, N. et al. 2013. Talanta. 116: 290-9.

PMID: 12364339 | Parkin accumulation in aggresomes due to proteasome impairment. | Junn, E. et al. 2002. J. Biol. Chem. 277: 47870-47877.

Ciatazioni 1 a9 di 9 totali
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