VEGF-C Antibody (F-5): sc-398004

VEGF-C Antibody (F-5) is a mouse monoclonal IgM antibody that detects VEGF-C in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). VEGF-C is a crucial member of the vascular endothelial growth factor family, primarily known for its role in lymphangiogenesis, the formation of lymphatic vessels, which is essential for maintaining fluid homeostasis and immune responses. VEGF-C is predominantly expressed in lymphatic endothelial cells and plays a significant role in promoting the growth and survival of these cells. Importantly, VEGF-C interacts with specific receptors, such as Flt-4 and Flk-1, which are vital for mediating effects on vascular permeability and endothelial cell proliferation. Dysregulation of VEGF-C signaling has been implicated in various pathological conditions, including cancer metastasis and lymphedema, making VEGF-C a critical target for therapeutic intervention. anti-VEGF-C antibody (F-5) provides a reliable tool for researchers investigating the complex mechanisms of angiogenesis and lymphangiogenesis, contributing to a deeper understanding of these processes in health and disease.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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VEGF-C Antibody (F-5) References:

1. Serum VEGF and VEGF-C values before surgery and after postoperative treatment in gastric cancer.  |  Villarejo-Campos, P., et al. 2013. Clin Transl Oncol. 15: 265-70. PMID: 22855190
2. Associations of nm23H1, VEGF-C, and VEGF-3 receptor in human prostate cancer.  |  Yang, ZS., et al. 2014. Molecules. 19: 6851-62. PMID: 24858271
3. Lymphangiogenesis in gastric cancer regulated through Akt/mTOR-VEGF-C/VEGF-D axis.  |  Chen, H., et al. 2015. BMC Cancer. 15: 103. PMID: 25884175
4. Critical requirement of VEGF-C in transition to fetal erythropoiesis.  |  Fang, S., et al. 2016. Blood. 128: 710-20. PMID: 27343251
5. VEGF-C Induces Alternative Activation of Microglia to Promote Recovery from Traumatic Brain Injury.  |  Ju, S., et al. 2019. J Alzheimers Dis. 68: 1687-1697. PMID: 30958378
6. VEGF-C induced by TGF- β1 signaling in gastric cancer enhances tumor-induced lymphangiogenesis.  |  Pak, KH., et al. 2019. BMC Cancer. 19: 799. PMID: 31409309
7. DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination.  |  Wang, CA., et al. 2020. J Extracell Vesicles. 9: 1746529. PMID: 32341770
8. Coexpression of TLR9 and VEGF-C is associated with lymphatic metastasis in prostate cancer.  |  Zeng, XZ., et al. 2022. Asian J Androl. 24: 380-385. PMID: 34643549
9. Co-expression of VEGF-C and survivin predicts poor prognosis in esophageal squamous cell carcinoma.  |  Zeng, YZ., et al. 2021. Transl Cancer Res. 10: 210-222. PMID: 35116253
10. Antibody-Mediated Delivery of VEGF-C Promotes Long-Lasting Lymphatic Expansion That Reduces Recurrent Inflammation.  |  Cousin, N., et al. 2022. Cells. 12: PMID: 36611965

The preferred VEGF-C antibody is VEGF-C Antibody (E-6): sc-374628.