Valproic Acid beta-D-Glucuronide Allyl Ester MF: C17H28O8
MW: 360.40
A glucuronide metabolite of Valproic Acid and reported HDAC inhibitor in vivo.

Valproic Acid β-D-Glucuronide Allyl Ester

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Applicazione: Valproic Acid β-D-Glucuronide Allyl Ester is a glucuronide metabolite of Valproic Acid and reported HDAC inhibitor in vivo
Peso molecolare: 360.40
Formula molecolare: C17H28O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
DISCOUNT: Bulk orders of Chemicals totaling $1,000 or more receive a 5% discount.
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Valproic Acid β-D-Glucuronide Allyl Ester is a glucuronide metabolite of Valproic Acid. In studies with sheep, Valproic Acid is believed to be predominately excreted through glucuronidation, as recovered in urine specimens. The parent compound, Valproic Acid is a branched chain, fatty acid which is reported to potentially enhance central GABAergic neurotransmission and inhibit Na+ channels. Currently, the various molecular mechanisms of action of Valproic Acid have not been completely elucidated. Valproic Acid has been reported to be a potent inhibitor of histone deacetylases (HDACs) in vitro. Valproic Acid is also noted to relieve HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. In animal studies, Valproic Acid has been observed to reduce tumor growth and metastasis formation. Additionally, Valproic Acid is reported to activate Wnt-dependent gene expression and to mimic trichostatin A (sc-3511) in the inhibition of histone deacetylase.

Metabolites of Valproic Acid are also available as:
Valproic Acid (sc-213144)
Valproic Acid, Sodium Salt (sc-202378)
3-Hydroxy Valproic Acid (sc-209599)
3-Keto Valproic Acid Sodium Salt (sc-216476)
4-Hydroxy Valproic Acid Sodium Salt(Mixture of Diastereomers) (sc-216870)
rac 5-Hydroxy Valproic Acid Sodium Salt (sc-208266)
Valproic Acid β-D-Glucuronide (sc-213145)

Labelled forms of Valproic Acid are available as:
Valproic Acid-d6 (sc-213146)
Valproic Acid-d6 β-D-Glucuronide (sc-220361)
rac 5-Hydroxy Valproic Acid-d7 Sodium Salt (sc-219789)


Referenze

1. Nagai, K., et al. 1997. J. Antimicrob. Chemother. 39: 295-296. PMID: 9069562
2. Yamamura, N., et al. 1999. Drug Metab. Dispos. 27: 724-730. PMID: 10348803
3. Yu, H.Y. and Shen, Y.Z. 2002. J. Pharm. Pharmacol. 54: 633-639. PMID: 12005358
4. Wong, H., et al. 2007. Drug Metab. Dispos. 35: 1380-1386. PMID: 17496206

Aspetto :
Oil
Solubilità :
Soluble in DCM, DMSO and Methanol
CONSERVAZIONE :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
CCCC(CCC)C(=O)O[[email protected]]1OC([[email protected]](O)C(O)[[email protected]]1O)C(=O)OCC=C

Download SDS (MSDS)

CERTIFICATO DI ANALISI

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