Ubiquitin Isopeptidase Inhibitor I, G5 CAS: 108477-18-5
MF: C19H14N2O7S
MW: 414.4
A cell-permeable cross-conjugated unsaturated dienone compound.

Ubiquitin Isopeptidase Inhibitor I, G5 (CAS 108477-18-5)

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Ubiquitin Isopeptidase Inhibitor I, G5 is rated 5.0 out of 5 by 1.
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Nomi alternativi: 3,5-bis((4-Nitrophenyl)methylene)-1,1-dioxide, tetrahydro-4H-thiopyran-4-one
Applicazione: Ubiquitin Isopeptidase Inhibitor I, G5 is a cell-permeable cross-conjugated unsaturated dienone compound
Numero CAS: 108477-18-5
Purezza: ≥97%
Peso molecolare: 414.4
Formula molecolare: C19H14N2O7S
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).

Ubiquitin Isopeptidase Inhibitor I, G5 is a cell-permeable cross-conjugated α,β-unsaturated dienone compound reported to induce caspase activation and apoptosis via the apoptosome-independent mitochondrial pathway by selectively inhibiting ubiquitin isopeptidase activity. The cellular expression of Bax and Bak is essential for G5-activated apoptosis, while Bcl-2 appears to protect cells against the effect of G5. G5 is reported to exhibit similar pharmacological effects as Ubiquitin Isopeptidase Inhibitor II, F6 but is reported to be more potent (sc-296678). Additionally, at higher concentrations, it has been shown to induce necrosis in apoptosis-resistant MEFs-DKO.


Referenze

1. Aleo, E., et al. 2006. Cancer Res. 66: 9235-9244. PMID: 16982768
2. Fontanini, A., et al. 2009. J. Biol. Chem. 284: 8369-8381. PMID: 19139105

Stato fisico :
Solid
Solubilità :
Solubility: DMSO
CONSERVAZIONE :
Store at 4° C
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
PubChem CID :
SMILES :
O=C1/C(=C/c2ccc(cc2)[N+](=O)[O-])/CS(=O)(=O)C/C/1=C\\c1ccc(cc1)[N+](=O)[O-]

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Ubiquitin Isopeptidase Inhibitor I, G5 (CAS 108477-18-5)  Citazioni prodotti

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PMID: # 25959059  Koumbadinga, GA. et al. 2015. Biochimica et biophysica acta. 1849: 1095-103.

PMID: # 24985478  Rush, J.S. et al. 2014. Investigative ophthalmology & visual science. 55: 4691-9.

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