U-74389G CAS: 153190-29-5
MF: C37H50N6O2•C4H4O4
MW: 726.9
A potent inhibitor of superoxide-mediated lipid peroxidation.

U-74389G (CAS 153190-29-5)

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Sinonimo: 21-(4-(2,6-di-1-Pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl)-pregna-1,4,9(11)-triene-3,20-dione (Z)-2-butenedioate
Applicazione: A potent inhibitor of superoxide-mediated lipid peroxidation
Numero CAS: 153190-29-5
Purezza: ≥98%
Peso molecolare: 726.9
Formula molecolare: C37H50N6O2•C4H4O4
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U-74389G is a nonglucocorticoid 21-aminosteroid that acts as a potent inhibitor of superoxide-mediated lipid peroxidation and has strong antioxidant activity. The compound has particularly strong antioxidant activity in a membranous system, and can interact with and be transported across lipid membrane models. Studies show that U-74389G can inhibit lipid peroxidation in different experimental systems such as cultured brain microvessel endothelial cells, Cu2+ treated monocytic THP1 cells, and LLC-PK1 cell layers, where F2 isoprostane production is blocked by the compound. Research indicates that cold storage with addition of U-74389G helps preserve small intestinal mucosa.


Referenze

1. Crutchley, D.J., et al. 1995. Circulation. 92: 238-243. PMID: 7600656
2. Shi, F., et al. 1995. Free Radic. Biol. Med. 19: 349-357. PMID: 7557549
3. Salahudeen, A., et al. 1995. J. Am. Soc. Nephrol. 6: 1300-1303. PMID: 8589301
4. Katz, S.M., et al. 1995. Transplantation. 59: 694-698. PMID: 7886794
5. Campo, G.M., et al. 1996. J. Pharmacol. Exp. Ther. 277: 333-340. PMID: 8613938
6. Saija, A., et al. 2001. Life Sci. 68: 1351-1366. PMID: 11388688

Stato fisico :
Solid
Solubilità :
Soluble in ethanol (20 mg/ml), methanol, DMSO (25 mg/ml), DMF (36 mg/ml), and 1:1 DMSO:PBS (pH 7.2) (~0.05 mg/ml). Insoluble in water.
CONSERVAZIONE :
Store at -20° C
IC50 :
Mycobacterium Tuberculosis: IC50 = 22.52 µM (7H9 Media); Mycobacterium Tuberculosis: IC50 = 38.5 µM (in the absence of Glycerol)
Valori pK :
pKb: 12.04
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
PubChem CID :
9896684
Numero MDL :
MFCD01074991
SMILES :
C[[email protected]]12CC=C3[[email protected]]([[email protected]@H]1CC[[email protected]@H]2C(=O)CN4CCN(CC4)C5=NC(=NC(=C5)N6CCCC6)N7CCCC7)CCC8=CC(=O)C=C[[email protected]@]83C.C(=C\\C(=O)O)\\C(=O)O

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U-74389G  Citazioni prodotti

Vedi quanti altri hanno usato U-74389G. Clicca sulla voce per laccesso a PubMed .

Ciatazioni 1 a2 di 2 totali

PMID: # 7600656  Crutchley, DJ. et al. 1995. Circulation. 92: 238-243.

PMID: # 8589301  Salahudeen, A. et al. 1995. J. Am. Soc. Nephrol. 6: 1300-1303.

Ciatazioni 1 a2 di 2 totali
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