Tris DBA chloroform adduct CAS: 52522-40-4
MF: Pd2(C17H14O)3•CHCl3
MW: 1035.10
An NMT1 inhibitor with antiproliferative properties.

Tris DBA chloroform adduct (CAS 52522-40-4)

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Nomi alternativi: Tris(dibenzylideneacetone)dipalladium(0)-chloroform adduct; Pd2(dba)3⋅CHCl3
Applicazione: Tris DBA chloroform adduct is an NMT1 inhibitor with antiproliferative properties
Numero CAS: 52522-40-4
Peso molecolare: 1035.10
Formula molecolare: Pd2(C17H14O)3•CHCl3
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
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Tris DBA chloroform adduct is an n-myristoyltransferase-1 (NMT1) inhibitor that prevents activation of MAPK, PI 3-K and STAT3 signaling pathways. It can be used as a cyclization catalyst. Tris DBA chloroform adduct also exhibits antiproliferative activity against melanoma cells in vitro.


Referenze

1. Bhandarkar, Sulochana S., et al., 2008. Tris (dibenzylideneacetone) dipalladium, a N-myristoyltransferase-1 inhibitor, is effective against melanoma growth in vitro and in vivo. Clinical cancer research : an official journal of the American Association for Cancer Research. 14(18): 5743-8. PMID: 18794083

Stato fisico :
Solid
Solubilità :
Insoluble in water.
CONSERVAZIONE :
Store at room temperature
Punto di scioglimento :
131-135° C (lit.)
Punto di ebollizione :
400.7° C at 760 mmHg
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
PubChem CID :
Numero MDL :
MFCD00075479
SMILES :
C1=CC=C(C=C1)/C=C/C(=O)/C=C/C2=CC=CC=C2.C1=CC=C(C=C1)/C=C/C(=O)/C=C/C2=CC=CC=C2.C1=CC=C(C=C1)/C=C/C(=O)/C=C/C2=CC=CC=C2.C(Cl)(Cl)Cl.[Pd].[Pd]

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