Temocaprilat CAS: 110221-53-9
MF: C21H24N2O5S2
MW: 448.56
An ACE inhibitor and active metabolite of temocapril.

Temocaprilat (CAS 110221-53-9)

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Applicazione: Temocaprilat is an ACE inhibitor and active metabolite of temocapril
Numero CAS: 110221-53-9
Peso molecolare: 448.56
Formula molecolare: C21H24N2O5S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Temocaprilat is an antihypertensive and the active metabolite of temocapril. This compound inhibits ACE (angiotensin-converting enzyme), which catalyzes the conversion of angiotensin I to angiotensin II by cleaving a dipeptide from the C-terminus. Angiotensin II binds to angiotensin II receptors, causing vasoconstriction and an increase in bloodpressure. Furthermore, the binding of angiotensin II causes the release of aldosterone, which causes reabsorption of water and sodium in the distal tubule.


Referenze

Qizumi, K., et al.: Jpn. J. Pharmacol., 48, 349 (1988) Arita, M., et al.: Clin. Exp. Pharmacol. Physiol., 21, 195 (1994) Tokunaga, S., et al.: Drug Invest., 7, 161 (1994)

Stato fisico :
Solid
Solubilità :
Soluble in DMSO.
CONSERVAZIONE :
Store at -20° C
Punto di scioglimento :
228-230° C
Punto di ebollizione :
~743.6° C at 760 mmHg (Predicted)
Densità :
~1.4 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.67 (Predicted)
Attività ottica :
α20/D 63.4°, c = 1 in DMF
IC50 :
Angiotensin-converting enzyme: IC50 = 3.6 nM (European rabbit)
Ki Data :
Canalicular multispecific organic anion transporter 1: Ki= 343 µM (rat)
Valori pK :
pKa: 2.09 (Predicted), pKb: 7.49 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
Numero MDL :
MFCD00871951
SMILES :
OC(=O)CN1C[[email protected]](SC[[email protected]](N[[email protected]@H](CCC2=CC=CC=C2)C(O)=O)C1=O)C1=CC=CS1

Download SDS (MSDS)

CERTIFICATO DI ANALISI

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