TCPOBOP CAS: 76150-91-9
MF: C16H8Cl4N2O2
MW: 402.06
The most potent activator of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents..

TCPOBOP (CAS 76150-91-9)

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Nomi alternativi: 1,4-bis(2-(3,5-dichloropyridyloxy))benzene
Applicazione: TCPOBOP is the most potent activator of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents.
Numero CAS: 76150-91-9
Purezza: ≥98%
Peso molecolare: 402.06
Formula molecolare: C16H8Cl4N2O2
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
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TCPOBOP is the most potent known member of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents. TCPOBOP induces activity of ER1 cytochrome P450 isozymes, NADPH-cytochrome c reductase, microsomal epoxide hydrolase and glutathione S transferase. Potent mitogen; induces liver cell proliferation in mice TCPOBOP acts as a tumor promoter of murine hepatocarcinogenesis; activates orphan nuclear receptors mCAR (mouse Constitutive Androstane Receptor) and hPXR(human Pregnane X Receptor), but has little or no activity on hCAR and mPXR. Additionally, TCPOBOP also suppresses the multidrug resistance gene expression in mouse liver cells.


Referenze

Ledda-Columbano, G.M., et al. 2000. Am. J. Pathol. 156, 91. Moore, L.B., et al. 2000. J. Biol. Chem. 275, 15122. Tzameli, I., et al. 2000. Mol. Cell. Biol. 20, 2951. Forman, B.M., et al. 1998. Nature 395, 612. Honkakoski, P., et al. 1998. Mol. Pharmacol. 53, 597. Russell, A.L., et al. 1994. Int. J. Cancer 58, 550. Smith, G., et al. 1993. Biochem. J. 289, 807. Dargani, T.A., et al. 1990. Carcinogenesis 11, 1153. Poland, A., et al. 1980. Mol. Pharmacol. 18, 571. R: 40; S: 22-36

Utilizzo :
Store as supplied, at room temperature for up to 1 year.Store solutions at -20°C for up to 3 months.
Stato fisico :
Solid
Solubilità :
Soluble in DMSO (5 mg/ml). Insoluble in water.
CONSERVAZIONE :
Store at room temperature
Punto di scioglimento :
155-157° C
Punto di ebollizione :
444.8° C at 760 mmHg (Predicted)
Densità :
~1.5 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.64 (Predicted)
IC50 :
HEK293 : EC5050 = 50 nM (human)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
RTECS :
UT7145000
PubChem CID :
Numero MDL :
MFCD00057368
SMILES :
C1=CC(=CC=C1OC2=C(C=C(C=N2)Cl)Cl)OC3=C(C=C(C=N3)Cl)Cl

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TCPOBOP (CAS 76150-91-9)  Citazioni prodotti

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PMID: # 33761883  Goldfarb, CN.|Waxman, DJ.| et al. 2021. BMC Genomics. 22: 212.

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