Tautomycin from Streptomyces spiroverticillatus CAS: 109946-35-2
MF: C41H66O13
Tautomycin is a potent and specific PP1 and PP2 inhibitor.

Tautomycin from Streptomyces spiroverticillatus (CAS 109946-35-2)

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Schede tecniche

Applicazione: Tautomycin is a potent and specific PP1 and PP2 inhibitor
Numero CAS: 109946-35-2
Peso molecolare: 766.95
Formula molecolare: C41H66O13
Informazioni supplementari: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Tautomycin is a potent and specific protein phosphatase inhibitor that functions as an antifungal antibiotic. Protein phosphatase-1 (Kiapp = 0.16 nM) (PP1) is more potently inhibited by tautomycin than protein phosphatase 2A (Kiapp = 0.4 nM) (PP2). Studies show that in the presence of tautomycin the expression levels of transferring receptor (TFR) increase and it also blocks PDBu-induced down regulation of CD4. Medullary thyroid cancer (MTC) cells treated with tautomycin and tautomycetin, also an antifungal antibiotic, showed suppressed levels of hormonal secretion, decreased neuroendocrine markers, and inhibition of growth through apoptosis. Both compounds, tautomycin and tautomycetin, can inhibit the growth of MTC cells by blocking glycogen synthase kinase-3β. Tautomycin can also activate the Raf-1 pathway, prevent neuroendocrine (NE) production, and decrease carcinoid cell development.

Stato fisico :
Solid
Derivato da :
Streptomyces spiroverticillatus
Solubilità :
Soluble in 100% ethanol, methanol, ethyl aceethyl acetate, DMSO, acetone, water (slightly), and chloroform.
CONSERVAZIONE :
Store at -20° C
IC50 :
Protein-tyrosine phosphatase 1B: IC50 = 0.67 nM (human); Serine/threonine protein phosphatase PP1-gamma catalytic subunit: IC50 = 0.7 nM (human); Serine-threonine protein phosphatase 2A regulatory subunit: IC50 = 0.7 nM (Gallus gallus); Serine/threonine protein phosphatase PP1-alpha catalytic subunit: IC50 = 0.7 nM (human)
Valori pK :
pKa: 12.33 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :

Download SDS (MSDS)

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