Tandutinib CAS: 387867-13-2
MF: C31H42N6O4
MW: 562.7
A piperazinyl quinazoline receptor tyrosine kinase inhibitor.

Tandutinib (CAS 387867-13-2)

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Applicazione: Tandutinib is A piperazinyl quinazoline receptor tyrosine kinase inhibitor
Numero CAS: 387867-13-2
Purezza: ≥99%
Peso molecolare: 562.7
Formula molecolare: C31H42N6O4
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
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Tandutinib is a piperazinyl quinazoline receptor tyrosine kinase inhibitor with antineoplastic activity. Tandutinib inhibits the autophosphorylation of Flt-3/Flk-2 (FMS-Like Tyrosine kinase-3), c-KIT and PDGF (platelet-derived growth factor) receptor tyrosine kinases, thereby inhibiting cellular proliferation and inducing apoptosis. Tandutinib is an inhibitor of PDGFR-beta.


Referenze

1. Brownlow, N., et al. 2008. Leukemia. 22: 1452-1453. PMID: 18185521
2. DeAngelo, D.J., et al. 2006. Blood. 108: 3674-3681. PMID: 16902153

Aspetto :
Powder
Stato fisico :
Solid
Solubilità :
Soluble in water (very poorly), DMSO (25 mg/ml, with slight warming), ethanol (25 mg/ml, with slight warming), and chloroform.
CONSERVAZIONE :
Store at -20° C
Punto di scioglimento :
172-183° C (lit.)
Punto di ebollizione :
769.50° C at 760 mmHg (Predicted)
Densità :
1.21 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.61 (Predicted)
IC50 :
human Kasumi-1 cells: IC50 = 22 nM (human); PDGFR-β: IC50 = 26 nM (human); MV4-11: IC50 = 55 nM (human); Flt-3/Flk-2: IC50 = 86.5 nM (human); c-Kit: IC50 = 0.17 µM
Ki Data :
PDGFR-β: Ki= 50.12 nM (human); M-CSF: Ki= 199.53 nM (human); CLK4: Ki= 398.11 nM (human); Flt-3/Flk-2: Ki= >794.33 nM (human); Emt: Ki= 1.26 µM (human)
Valori pK :
pKa: 13.39 (Predicted), pKb: 9.48 (Predicted)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
PubChem CID :
Numero MDL :
MFCD09954147
SMILES :
CC(C)OC1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCCC5

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