STAT3 Inhibitor VII CAS: 1041438-68-9
MF: C19H7F7N2O3
MW: 444.26
A cellular JAK1/JAK2/TYK2/STAT3 activation inhibitor.

STAT3 Inhibitor VII (CAS 1041438-68-9)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 104ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Applicazione: STAT3 Inhibitor VII is a cellular JAK1/JAK2/TYK2/STAT3 activation inhibitor
Numero CAS: 1041438-68-9
Purezza: ≥95%
Peso molecolare: 444.26
Formula molecolare: C19H7F7N2O3
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
loading

STAT3 Inhibitor VII is a cell permeable dihydroquinoline that specifically inhibits JAK1, JAK2, TYK2, and STAT3. This pathway is important in cell proliferation and so this inhibitor is ideal to inhibit cell proliferation in cancer cells. STAT3 is part of the STAT family of proteins which are readily phosphorylated by receptor-associated kinases. Upon activation STAT proteins induce transcription factors. Studies involving IFNγ-activated human astrocytes indicate that STAT3 inhibitors can attenuate neutoxicity and inflammatory molecule production. In addition, studies suggest that STAT3 Inhibitor VII is an active suppressor of IL-23-induced expression of IL-23 receptor subunits in human SUPT-1T cells and in primary CD4 human T cells.


Referenze

1. Xu, J., et al. 2008. J. Med. Chem. 51: 4115-4121. PMID: 18578470
2. Che Mat, N.F., et al. 2010. J Interferon Cytokine Res. [Epub ahead of print]. PMID: 21138378
3. Hashioka, S., et al. 2011. Neurobiol. Dis. 41: 299-307. PMID: 20888416

Stato fisico :
Solid
Solubilità :
DMSO
CONSERVAZIONE :
Store at 4° C
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
PubChem CID :
SMILES :
CCOC(=O)C1=CN(C2=C(C(=C(C=C2C1=O)F)F)F)C3=C(C(=C(C(=C3F)F)C#N)F)F

Download SDS (MSDS)

CERTIFICATO DI ANALISI

Adobe Acrobat Reader necessario per una visualizzazione affidabile,
stampa e commenta sui documenti PDF

STAT3 Inhibitor VII (CAS 1041438-68-9)  Citazioni prodotti

Vedi quanti altri hanno usato STAT3 Inhibitor VII (CAS 1041438-68-9). Clicca sulla voce per laccesso a PubMed .

Ciatazioni 1 a1 di 1 totali

PMID: # 26472924  Fang, Y. et al. 2015. J. Biol. Chem. 290: 28901-14.

Ciatazioni 1 a1 di 1 totali
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 112ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 7ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;