Stat3 Inhibitor VI, S3I-201 Stat3 Inhibitor VI, S3I-201 is an inhibitor of Stat3 phosphorylation and dimerization.

Stat3 Inhibitor VI, S3I-201 (CAS 501919-59-1)

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Nomi alternativi: 2-Hydroxy-4-(((4-methylphenyl)sulfonyloxy)acetyl)amino)-benzoic acid; S3I-201
Applicazione: Stat3 Inhibitor VI, S3I-201 is an inhibitor of Stat3 phosphorylation and dimerization
Numero CAS: 501919-59-1
Purezza: ≥95%
Peso molecolare: 365.36
Formula molecolare: C16H15NO7S
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
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S31-201 inhibits the Stat3 transcription factor by blocking the phosphorylation and dimerization events necessary for activation. Many cancers express aberrant behavior in the Stat3 growth factor, making this compound a valuable tool for perturbing the chemistry of such systems. Another Stat3 inhibitor is Stattic (sc-202818).


Referenze

1. Siddiquee, K., et al. 2007. Proc. Natl. Acad. Sci. U.S.A. 104: 7391-7396. PMID: 17463090

Utilizzo :
• Use only fresh, anhydrous DMSO.

• Protect from light.

• Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Stato fisico :
Solid
Solubilità :
Soluble in DMSO (73 mg/ml at 25° C), water (<1 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
CONSERVAZIONE :
Store at -20° C
Punto di scioglimento :
265.49° C (Predicted)
Punto di ebollizione :
654.72° C at 760 mmHg (Predicted)
Densità :
1.51 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.64 (Predicted)
IC50 :
Stat3: IC50 = 86 µM; Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1: IC50 = 4.64 µM (human)
Valori pK :
pKa: 2.98 (Predicted)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
PubChem CID :
Numero MDL :
MFCD09907564
SMILES :
CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O

Download SDS (MSDS)

CERTIFICATO DI ANALISI

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Stat3 Inhibitor VI, S3I-201 (CAS 501919-59-1)  Citazioni prodotti

Vedi quanti altri hanno usato Stat3 Inhibitor VI, S3I-201 (CAS 501919-59-1). Clicca sulla voce per laccesso a PubMed .

Ciatazioni 1 a10 di 94 totali

PMID: # 33466434  Ou-Yang, H.|Wu, SC.|Sung, LY.|Yang, SH.|Yang, SH.|Chong, KY.|Chen, CM.| et al. 2021. Int J Mol Sci. 22:

PMID: # 33806019  Tsoi, H.|Man, EPS.|Chau, KM.|Khoo, US.| et al. 2021. Cancers (Basel). 13:

PMID: # 33614244  Guduric-Fuchs, J.|Pedrini, E.|Lechner, J.|Chambers, SEJ.|O'Neill, CL.|Mendes Lopes de Melo, J.|Pathak, V.|Church, RH.|McKeown, S.|Bojdo, J.|Mcloughlin, KJ.|Stitt, AW.|Medina, RJ.| et al. 2021. Mol Ther Nucleic Acids. 23: 968-981.

PMID: # 33876829  Han, Z.|Ma, Y.|Cao, G.|Ma, Z.|Chen, R.|Cvijic, ME.|Cheng, D.| et al. 2021. Biochem J.

PMID: # 34147561  Jin, A.|Tang, X.|Zhai, W.|Li, Y.|Sun, Q.|Liu, L.|Yang, X.|Ren, H.|Lu, S.| et al. 2021. Biochim Biophys Acta Mol Cell Res. 119083.

PMID: # 31593762  Leake, A.|Salem, K.|Madigan, MC.|Lee, GR.|Shukla, A.|Hong, G.|Zuckerbraun, BS.|Tzeng, E.| et al. 2020. Nitric Oxide. 94: 36-47.

PMID: # 31068940  Kunkl, M.|Mastrogiovanni, M.|Porciello, N.|Caristi, S.|Monteleone, E.|Arcieri, S.|Tuosto, L.| et al. 2019. Front Immunol. 10: 864.

PMID: # 31299319  Ahmad, SF.|Ansari, MA.|Nadeem, A.|Bakheet, SA.|Alanazi, AZ.|Alsanea, S.|As Sobeai, HM.|Almutairi, MM.|Mahmood, HM.|Attia, SM.| et al. 2019. Brain Res. Bull. 152: 27-34.

PMID: # 30504685  Tun, X.|Yasukawa, K.|Yamada, KI.| et al. 2018. Biol. Pharm. Bull. 41: 1843-1852.

PMID: # 30171910  Choi, DJ.|Kwon, JK.|Joe, EH.| et al. 2018. Neurosci Lett. 685: 144-149.

Ciatazioni 1 a10 di 94 totali
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