Stat3 inhibitor V, stattic CAS: 19983-44-9
MF: C8H5NO4S
MW: 211.19
An inhibitor of Stat3 activation.

Stat3 inhibitor V, stattic (CAS 19983-44-9)

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Stat3 inhibitor V, stattic is rated 4.67 out of 5 by 3.
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Nomi alternativi: 6-Nitrobenzo[b]thiophene-1,1-dioxide; 6-Nitrobenzo[b]thiophene-1,1-dioxide; Stat three inhibitory compound
Applicazione: Stat3 inhibitor V, stattic is an inhibitor of Stat3 activation
Numero CAS: 19983-44-9
Purezza: >95%
Peso molecolare: 211.19
Formula molecolare: C8H5NO4S
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
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Stat3 Inhibitor V, Stattic is a small molecule shown to selectively inhibit the activation of the Stat3 transcription factor by blocking phosphorylation and dimerization events. Stattic has been used as a tool for probing the upstream activation of this factor, significantly expressed in many cancer cell lines, and interruption of this pathway in breast cancer cell lines lead to an increased apoptotic rate in these cells. Stat3 Inhibitor V, Stattic is an inhibitor of Stat3.


Referenze

1. Schust, J., et al. 2006. Chem. Biol. 13: 1235-1242. PMID: 17114005

Stato fisico :
Solid
Solubilità :
Soluble in ethanol (5 mM), and DMSO (50 mM). Insoluble in water.
CONSERVAZIONE :
Store at -20° C
Punto di scioglimento :
129.80° C (Predicted)
Punto di ebollizione :
~461.1° C (Predicted)
Densità :
~1.6 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.67 (Predicted)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
PubChem CID :
Numero MDL :
MFCD00173799
SMILES :
C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]

Download SDS (MSDS)

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Stat3 inhibitor V, stattic (CAS 19983-44-9)  Citazioni prodotti

Vedi quanti altri hanno usato Stat3 inhibitor V, stattic (CAS 19983-44-9). Clicca sulla voce per laccesso a PubMed .

Ciatazioni 1 a10 di 95 totali

PMID: # 33708210  Wang, Z.|Guan, D.|Huo, J.|Biswas, SK.|Huang, Y.|Yang, Y.|Xu, S.|Lam, KP.| et al. 2021. Front Immunol. 12: 619195.

PMID: # 33544929  Kim, B.|Seo, Y.|Kwon, JH.|Shin, Y.|Kim, S.|Park, SJ.|Park, JJ.|Cheon, JH.|Kim, WH.|Il Kim, T.| et al. 2021. Mol Carcinog. 60: 188-200.

PMID: # 33769466  Fu, M.|Tan, L.|Lin, Z.|Lui, V.|Tam, PKH.|Lamb, J.|Zhang, Y.|Xia, H.|Zhang, R.|Chen, Y.| et al. 2021. Clin Sci (Lond).

PMID: # 33866491  Chalikonda, G.|Lee, H.|Sheik, A.|Huh, YS.| et al. 2021. Mol Cell Biochem. 476: 3219-3228.

PMID: # 34413847  Jeljeli, M.|Chêne, C.|Chouzenoux, S.|Thomas, M.|Segain, B.|Doridot, L.|Nicco, C.|Batteux, F.| et al. 2021. Front Immunol. 12: 670776.

PMID: # 34343540  Paddock, SJ.|Swift, SK.|Alencar-Almeida, V.|Kenarsary, A.|Alvarez-Argote, S.|Flinn, MA.|Patterson, M.|O'Meara, CC.| et al. 2021. J Mol Cell Cardiol.

PMID: # 31228946  Lu, C. et al. 2019. J Immunother Cancer. 7: 157.

PMID: # 31393941  Li, W.|Cho, MY.|Lee, S.|Jang, M.|Park, J.|Park, R.| et al. 2019. PLoS ONE. 14: e0220860.

PMID: # 30816423  Zhang, X.|Liu, S.|Wang, Y.|Hu, H.|Li, L.|Wu, Y.|Cao, D.|Cai, Y.|Zhang, J.|Zhang, X.| et al. 2019. Int. J. Mol. Med.

PMID: # 31214200  2019. Front Immunol. 10: 1267.

Ciatazioni 1 a10 di 95 totali
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