Stat3 Inhibitor III, WP1066 CAS: 857064-38-1
MF: C17H14BrN3O
MW: 356.2
A cell permeable inhibitor of Stat3 and JAK2 protein tyrosine kinase.

Stat3 Inhibitor III, WP1066 (CAS 857064-38-1)

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Nomi alternativi: (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide
Applicazione: Stat3 Inhibitor III, WP1066 is a cell permeable inhibitor of Stat3 and JAK2 protein tyrosine kinase
Numero CAS: 857064-38-1
Purezza: ≥97%
Peso molecolare: 356.2
Formula molecolare: C17H14BrN3O
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
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Stat3 inhibitor III, WP1066 (WP10666) is a cell permeable AG 490 tyrphostin analog that effectively inhibits the STAT3 pathway. The inhibitor is a potent antitumor agent as displayed in the growth inhibition of malignant glioma cell and acute myelogenous leukemia cells. Stat3 Inhibitor III, WP1066 has shown more potency as an antitumor agent than AG 490 (sc-202046) when inhibiting malignant glioma growth in vitro. WP1066 also acts as an immune adjuvant by inducing proliferation of effector T cells and upregulating CD86 and CD80. In addition WP1066 has displayed inhibition of JAK2 protein tyrosine kinase as well as suggested activation of Bax.


Referenze

1. Hussain, S.F., et al. 2007. Cancer Res. 67: 9630-9636. PMID: 17942891
2. Ferrajoli, A., et al. 2007. Cancer Res. 67: 11291-11299. PMID: 18056455
3. Iwamaru, A., et al. 2007. Oncogene. 26: 2435-2444. PMID: 17043651
4. McGaffin, K.R., et al. 2009. Cardiovasc. Res. 83: 313-324. PMID: 19233863

Stato fisico :
Solid
Solubilità :
DMSO or EtOH
CONSERVAZIONE :
Store at 4° C
Punto di scioglimento :
218.49° C (Predicted)
Punto di ebollizione :
569.88° C at 760 mmHg (Predicted)
Densità :
1.43 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.64 (Predicted)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
2
PubChem CID :
Numero MDL :
MFCD12912450
SMILES :
CC(C1=CC=CC=C1)NC(=O)C(=CC2=NC(=CC=C2)Br)C#N

Download SDS (MSDS)

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Stat3 Inhibitor III, WP1066 (CAS 857064-38-1)  Citazioni prodotti

Vedi quanti altri hanno usato Stat3 Inhibitor III, WP1066 (CAS 857064-38-1). Clicca sulla voce per laccesso a PubMed .

Ciatazioni 1 a10 di 65 totali

PMID: # 33790360  Suter, MA.|Tan, NY.|Thiam, CH.|Khatoo, M.|MacAry, PA.|Angeli, V.|Gasser, S.|Zhang, YL.| et al. 2021. Sci Rep. 11: 7243.

PMID: # 34466072  Ali, S.|Khan, MR.|Iqbal, J.|Batool, R.|Naz, I.|Yaseen, T.|Abbasi, BA.|Nasir, JA.|El-Serehy, HA.| et al. 2021. Saudi J Biol Sci. 28: 4969-4986.

PMID: # 30820808  Hosokawa, I.|Hosokawa, Y.|Ozaki, K.|Matsuo, T.| et al. 2019. Inflammation. 42: 1311-1316.

PMID: # 30483799  Vázquez-Mellado, MJ.|Cortés-Ballinas, LG.|Blanco-Flores, IC.|Aguilar, C.|Vázquez-Gómez, G.|Rocha-Zavaleta, L.| et al. 2019. Oncol Rep. 41: 1333-1341.

PMID: # 30816423  Zhang, X.|Liu, S.|Wang, Y.|Hu, H.|Li, L.|Wu, Y.|Cao, D.|Cai, Y.|Zhang, J.|Zhang, X.| et al. 2019. Int. J. Mol. Med.

PMID: # 29568942  Huang, G.|Huang, X.|Liu, M.|Hua, Y.|Deng, B.|Jin, W.|Yan, W.|Tan, Z.|Wu, Y.|Liu, B.|Zhou, Y.| et al. 2018. Int J Mol Med. 41: 3570-3576.

PMID: # 29658610  Chen, N.|Feng, L.|Qu, H.|Lu, K.|Li, P.|Lv, X.|Wang, X.| et al. 2018. Oncol. Rep. 39: 3064-3072.

PMID: # 30039429  Hosokawa, Y.|Hosokawa, I.|Ozaki, K.|Matsuo, T.| et al. 2018. Inflammation. 41: 2110-2115.

PMID: # 29998979  Miyasato, Y.|Takashima, Y.|Takeya, H.|Yano, H.|Hayano, A.|Nakagawa, T.|Makino, K.|Takeya, M.|Yamanaka, R.|Komohara, Y.| et al. 2018. J Clin Exp Hematop. 58: 95-101.

PMID: # 29981830  Cao, L.|Cao, X.|Zhou, Y.|Nagpure, BV.|Wu, ZY.|Hu, LF.|Yang, Y.|Sethi, G.|Moore, PK.|Bian, JS.| et al. 2018. Brain Behav. Immun. 73: 603-614.

Ciatazioni 1 a10 di 65 totali
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