Sos 1 Antibody (E-6): sc-376843

Sos 1 Antibody (E-6) is a mouse monoclonal IgG3 antibody that detects Sos 1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Sos 1 plays a crucial role as a guanine nucleotide exchange factor (GEF) that activates Ras proteins, which are pivotal in regulating various cellular processes, including growth, differentiation, and survival. The activation of Ras by Sos 1 is essential for the transmission of signals from cell surface receptors to downstream effectors, thereby influencing critical pathways such as the MAP kinase pathway. This interaction is particularly important in the context of cellular responses to growth factors and oncogenic signals, making Sos 1 a significant player in cancer biology and therapeutic targeting. Anti-Sos 1 antibody (E-6) provides reliable detection and quantification of Sos 1, facilitating research into functional dynamics and interactions within the Ras signaling cascade.

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Sos 1 Antibody (E-6) References:

1. Mechanisms through which Sos-1 coordinates the activation of Ras and Rac.  |  Innocenti, M., et al. 2002. J Cell Biol. 156: 125-36. PMID: 11777939
2. Novel amidine analogue of melphalan as a specific multifunctional inhibitor of growth and metabolism of human breast cancer cells.  |  Bielawski, K., et al. 2006. Biochem Pharmacol. 72: 320-31. PMID: 16730667
3. Abelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formation.  |  Proepper, C., et al. 2007. EMBO J. 26: 1397-409. PMID: 17304222
4. An activating mutation in sos-1 identifies its Dbl domain as a critical inhibitor of the epidermal growth factor receptor pathway during Caenorhabditis elegans vulval development.  |  Modzelewska, K., et al. 2007. Mol Cell Biol. 27: 3695-707. PMID: 17339331
5. SIRPalpha1 receptors interfere with the EGFRvIII signalosome to inhibit glioblastoma cell transformation and migration.  |  Kapoor, GS. and O'Rourke, DM. 2010. Oncogene. 29: 4130-44. PMID: 20473329
6. Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T cells leads to PI3K pathway activation and defects in migration.  |  Guittard, G., et al. 2015. Eur J Immunol. 45: 2389-95. PMID: 25973715
7. Differential Role of the RasGEFs Sos1 and Sos2 in Mouse Skin Homeostasis and Carcinogenesis.  |  Liceras-Boillos, P., et al. 2018. Mol Cell Biol. 38: PMID: 29844066
8. Frontline Science: TNF-α and GM-CSF1 priming augments the role of SOS1/2 in driving activation of Ras, PI3K-γ, and neutrophil proinflammatory responses.  |  Suire, S., et al. 2019. J Leukoc Biol. 106: 815-822. PMID: 30720883
9. Lipid raft protein flotillin-1 is important for the interaction between SOS1 and H-Ras/K-Ras, leading to Ras activation.  |  Jin, H., et al. 2023. Int J Cancer. 152: 1933-1946. PMID: 36691829
10. Combining SOS1 and MEK Inhibitors in a Murine Model of Plexiform Neurofibroma Results in Tumor Shrinkage.  |  Jackson, M., et al. 2023. J Pharmacol Exp Ther. 385: 106-116. PMID: 36849412

The preferred Sos 1 antibody is Sos 1 Antibody (A-9): sc-17793.