SN-6 CAS: 415697-08-4
MF: C20H22N2O5S
SN-6 is a selective Na+/Ca2+-exchange (NCX) inhibitor.

SN-6 (CAS 415697-08-4)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 145ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Nomi alternativi: 2-[[4-[(4-Nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylic acid ethyl ester
Applicazione: SN-6 is a selective Na+/Ca2+-exchange (NCX) inhibitor
Numero CAS: 415697-08-4
Purezza: ≥98%
Peso molecolare: 402.16
Formula molecolare: C20H22N2O5S
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).

SN-6 is a selective Na+/Ca2+exchange (NCX) inhibitor, displaying some selectivity for NCX1. IC50 values are 2.9, 16 and 8.6 μM for inhibition of intracellular Na+-dependent Ca2+ uptake by cells expressing NCX1, NCX2 and NCX3 respectively. SN-6 has some affinity for mACh receptors (IC50 = 18 μM) but minimal activity against NCKX2 and various receptors and ion channels (IC50 > 30 μM). Preferentially blocks Ca2+ influx mode and is more selective for NCX isoforms than KB-R7943. This compound acts as an anti-ischemic, potently protecting against hypoxia-induced renal tubular cell damage (IC50 = 0.63 μM).


Referenze

1. Inoue, Y., Ito, K., Sakaue, T., Iwamoto, T. and Kita, S. 2004. Characterization of SN-6, a novel exchange inhibitor and its renal protective effect]. Clin Calcium. 14(8): 84-91. PMID: 15577102

2. Iwamoto, T. 2004. Forefront of Na+/Ca2+ exchanger studies: molecular pharmacology of Na+/Ca2+ exchange inhibitors. J. Pharmacol. Sci. 96(1): 27-32. PMID: 15359084

3. Iwamoto, T., Inoue, Y., Ito, K., Sakaue, T., Kita, S. and Katsuragi, T. 2004. The exchanger inhibitory peptide region-dependent inhibition of Na+/Ca2+ exchange by SN-6 [2-[4-(4-nitrobenzyloxy)benzyl]thiazolidine-4-carboxylic acid ethyl ester], a novel benzyloxyphenyl derivative. Mol. Pharmacol. 66(1): 45-55. PMID: 15213295

4. Iwamoto, T. and Kita, S. 2006. YM-244769, a novel Na+/Ca2+ exchange inhibitor that preferentially inhibits NCX3, efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. Mol. Pharmacol. 70(6): 2075-2083. PMID: 16973719

Stato fisico :
Solid
Solubilità :
Soluble in DMSO (100 mM).
CONSERVAZIONE :
Desiccate at 4° C
Punto di scioglimento :
222.14° C (Predicted)
Punto di ebollizione :
~581.2° C at 760 mmHg (Predicted)
Densità :
~1.3 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.61 (Predicted)
IC50 :
Hypoxia-induced renal tubular cell damage: IC50 = 0.63 µM; Intracellular Na+-dependent 45Ca2+ uptake by cells expressing NCX1: IC50 = 2.9 µM; Intracellular Na+-dependent 45Ca2+ uptake by cells expressing NCX3: IC50 = 8.6 µM; Intracellular Na+-dependent 45Ca2+ uptake by cells expressing NCX2: IC50 = 16 µM; mACh receptors : IC50 = 18 µM
Valori pK :
pKb: 6.63 (Predicted)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
PubChem CID :
Numero MDL :
MFCD06798326
SMILES :
CCOC(=O)C1CSC(N1)CC2=CC=C(C=C2)OCC3=CC=C(C=C3)[N+](=O)[O-]

Download SDS (MSDS)

CERTIFICATO DI ANALISI

Adobe Acrobat Reader necessario per una visualizzazione affidabile,
stampa e commenta sui documenti PDF

SN-6 (CAS 415697-08-4)  Citazioni prodotti

Vedi quanti altri hanno usato SN-6 (CAS 415697-08-4). Clicca sulla voce per laccesso a PubMed .

Ciatazioni 1 a2 di 2 totali

PMID: # 30892074  Amarelle, L. et al. 2019. Am. J. Physiol. Lung Cell Mol. Physiol. 316: L1094-L1106.

PMID: # 26418956  van der Hagen, EA.|van Loon, EP.|Verkaart, S.|Latta, F.|Bindels, RJ.|Hoenderop, JG.| et al. 2015. Nephron. 131: 145-52.

Ciatazioni 1 a2 di 2 totali
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 193ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 6ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

La Santa Cruz Biotechnology, Inc. è un leader mondiale nello sviluppo di prodotti per il mercato della ricerca biomedica. Chiamaci al numero gratuito 1-800-457-3801.
Copyright © 2007-2021 Santa Cruz Biotechnology, Inc. Tutti i diritti riservati. "Santa Cruz Biotechnology", ed il logo Santa Cruz Biotechnology, Inc."Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", il logo San Juan Ranch, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", ed "EZ Touch" sono marchi registrati dalla Santa Cruz Biotechnology, Inc.
Tutti i marchi sono proprietà dei rispettivi proprietari.