SKF 89976A hydrochloride is a potent inhibitor of GABA (sc-203053) uptake. SKF 89976A is described to be highly selective for the GAT-1 (GABA T-1) protein, demonstrating high affinity at cloned human GABA T-1 (IC50 = 0.13 μM) and rat GABA T-1 (IC50 = 0.64 μM) for inhibition of [3H]GABA uptake with very low affinity at rat GABA T-2 (IC50 = 550 μm) and human GABA T-3 (IC50 = 944 μM).
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