Sandramycin is a cyclic depsipeptide natural product antibiotic. Sandramycin is described to bisintercalate DNA strands through its two pendant quinoline moeities. This bisintercalation mechanism translates to a potent antitumor activity correlated with Sandramycin.
1. Matson, J.A. and Bush, J.A. 1989. J. Antibiot. 42: 1763-1767. PMID: 2621159
2. Matson, J.A., et al. 1993. J. Antibiot. 46: 162-166. PMID: 8436549