Date published: 2026-4-23

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S15535 (CAS 146998-34-7)

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Alternate Names:
1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-4-(2,3-dihydro-1h-inden-2-yl)-piperazine
Application:
S15535 is a partial SR-1A (5-HT1A) receptor agonist
CAS Number:
146998-34-7
Molecular Weight:
336.43
Molecular Formula:
C21H24N2O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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S15535, identified as 1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-4-(2,3-dihydro-1h-inden-2-yl)-piperazine, is a compound of interest in the realm of chemical research, particularly in the areas of neuroscience and receptor pharmacology. This compound is structurally designed to interact with specific neurotransmitter receptors, which allows researchers to study receptor binding dynamics, signaling pathways, and the modulation of neuronal activity. In studies focused on the central nervous system, S15535 is used to investigate its affinity and selectivity towards serotonergic receptors, which is useful for understanding the role of these receptors in various neurological processes. Additionally, the compound′s influence on receptor-mediated ion flux can be examined in electrophysiological studies, providing insights into the functional consequences of receptor activation or inhibition. Research involving S15535 aids in the exploration of molecular mechanisms underlying neurotransmitter function and the potential discovery of novel compounds with specific receptor activity profiles.


S15535 (CAS 146998-34-7) References

  1. The 5HT(1A) receptor ligand, S15535, antagonises G-protein activation: a [35S]GTPgammaS and [3H]S15535 autoradiography study.  |  Newman-Tancredi, A., et al. 1999. Eur J Pharmacol. 384: 111-21. PMID: 10611431
  2. The selective serotonin (5-HT)1A receptor ligand, S15535, displays anxiolytic-like effects in the social interaction and Vogel models and suppresses dialysate levels of 5-HT in the dorsal hippocampus of freely-moving rats. A comparison with other anxiolytic agents.  |  Dekeyne, A., et al. 2000. Psychopharmacology (Berl). 152: 55-66. PMID: 11041316
  3. Antibody capture assay reveals bell-shaped concentration-response isotherms for h5-HT(1A) receptor-mediated Galpha(i3) activation: conformational selection by high-efficacy agonists, and relationship to trafficking of receptor signaling.  |  Newman-Tancredi, A., et al. 2002. Mol Pharmacol. 62: 590-601. PMID: 12181435
  4. Comparison of hippocampal G protein activation by 5-HT(1A) receptor agonists and the atypical antipsychotics clozapine and S16924.  |  Newman-Tancredi, A., et al. 2003. Naunyn Schmiedebergs Arch Pharmacol. 368: 188-99. PMID: 12923612
  5. The serotonin1A receptor partial agonist S15535 [4-(benzodioxan-5-yl)1-(indan-2-yl)piperazine] enhances cholinergic transmission and cognitive function in rodents: a combined neurochemical and behavioral analysis.  |  Millan, MJ., et al. 2004. J Pharmacol Exp Ther. 311: 190-203. PMID: 15146031
  6. Bidirectional modulation of classical fear conditioning in mice by 5-HT(1A) receptor ligands with contrasting intrinsic activities.  |  Youn, J., et al. 2009. Neuropharmacology. 57: 567-76. PMID: 19607850
  7. Serotonin 5-HT1A Receptor Biased Agonists Display Differential Anxiolytic Activity in a Rat Social Interaction Model.  |  Depoortère, R., et al. 2019. ACS Chem Neurosci. 10: 3101-3107. PMID: 30929419
  8. Pharmacological Studies on the Role of 5-HT1 A Receptors in Male Sexual Behavior of Wildtype and Serotonin Transporter Knockout Rats.  |  Esquivel-Franco, DC., et al. 2020. Front Behav Neurosci. 14: 40. PMID: 32296313

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

S15535, 5 mg

sc-250959
5 mg
$208.00