(S)-SNAP 5114 CAS: 157604-55-2
MF: C30H35NO6
MW: 505.61
A GABA uptake inhibitor that increases thalamic GABA levels.

(S)-SNAP 5114 (CAS 157604-55-2)

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Nomi alternativi: (S)-1-[2-[Tris(4-methoxyphenyl)methoxy]ethyl]-3-piperidinecarboxylic acid
Applicazione: (S)-SNAP 5114 is a GABA uptake inhibitor that increases thalamic GABA levels
Numero CAS: 157604-55-2
Purezza: ≥98%
Peso molecolare: 505.61
Formula molecolare: C30H35NO6
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
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(S)-SNAP 5114 is a GABA uptake inhibitor, showing selectivity for GABA T-3 and GABA T-2 (IC50 values are 5, 21 and 388 μM for hGABA T-3, rGABA T-2 and hGABA T-1 respectively). Increases thalamic GABA levels.


Referenze

Borden et al (1994) Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site. Receptors Channels 2 207. Borden (1996) GABA transporter heterogeneity: pharmacology and cellular localization. Neurochem.Int. 29 335. Dalby (2000) GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors. Neuropharmacology 39 2399.

Stato fisico :
Solid
Solubilità :
Soluble in DMSO (>5 mg/ml), and ethanol (50 mM). Insoluble in water.
CONSERVAZIONE :
Store at -20° C
Punto di ebollizione :
643.92° C at 760 mmHg (Predicted)
Densità :
1.18 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.57 (Predicted)
IC50 :
GABA transporter 4: IC50 = 1.55 µM (mouse); hGAT-3: IC50 = 5 µM; GABA transporter 3: IC50 = 5 µM (human); rGAT-2: IC50 = 21 µM; hGAT-1: IC50 = 388 µM
Valori pK :
pKa: 3.85 (Predicted), pKb: 9.35 (Predicted)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
PubChem CID :
Numero MDL :
MFCD06411702
SMILES :
COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)OCCN4CCC[[email protected]](C4)C(=O)O

Download SDS (MSDS)

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