S-antigen Antibody (PFS-1): sc-52208

S-antigen Antibody (PFS-1) is a mouse monoclonal IgG1 antibody that detects the S-antigen protein of Plasmodium falciparum origin by western blotting (WB). Anti-S-antigen antibody (PFS-1) is available as the non-conjugated format. Plasmodium falciparum, the protozoan parasite responsible for malaria, exhibits significant antigenic diversity, which poses a challenge in the development of effective vaccines. S-antigen is a crucial protein located in the parasitophorous vacuole of the mature asexual intraerythrocytic stage of the parasite, playing a vital role in survival and immune evasion. S-antigen gene is characterized by multiple alleles originating from the same chromosomal site, with each allele featuring a central region of tandemly arranged, nearly identical peptides that are specific to that allele. This structural diversity allows for the identification of distinct serotypes based on the repeat region, while the flanking non-repetitive sequences, which vary among four different forms, help define individual S-antigen families. Notably, the variation is most pronounced in the C-terminal-flanking region, underscoring the importance of understanding these structural differences for vaccine development and diagnostic purposes.

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S-antigen Antibody (PFS-1) References:

1. Geographical structure and sequence evolution as inferred from the Plasmodium falciparum S-antigen locus.  |  Anderson, TJ. and Day, KP. 2000. Mol Biochem Parasitol. 106: 321-6. PMID: 10699263
2. A fourth family of the Plasmodium falciparum S-antigen.  |  Bickle, Q. and Coppel, RL. 1992. Mol Biochem Parasitol. 56: 141-50. PMID: 1474992
3. Chemical crosslinking of Plasmodium falciparum glycoprotein, Pf200 (190-205 kDa), to the S-antigen at the merozoite surface.  |  Perkins, ME. and Rocco, LJ. 1990. Exp Parasitol. 70: 207-16. PMID: 2404782
4. S-antigen localization in the erythrocytic stages of Plasmodium falciparum.  |  Culvenor, JG. and Crewther, PE. 1990. J Protozool. 37: 59-65. PMID: 2406433
5. Small area variation in prevalence of an S-antigen serotype of Plasmodium falciparum in villages of Madang, Papua New Guinea.  |  Forsyth, KP., et al. 1989. Am J Trop Med Hyg. 40: 344-50. PMID: 2653060
6. An S antigen gene from Plasmodium falciparum contains a novel repetitive sequence.  |  Nicholls, SC., et al. 1988. Mol Biochem Parasitol. 28: 11-9. PMID: 2836730
7. The S-antigen of Plasmodium falciparum Palo Alto represents a new S-antigen serotype.  |  Mattei, D., et al. 1988. Mol Biochem Parasitol. 27: 171-80. PMID: 3278225
8. Changes in repeat number, sequence, and reading frame in S-antigen genes of Plasmodium falciparum.  |  Saint, RB., et al. 1987. Mol Cell Biol. 7: 2968-73. PMID: 3313007
9. Sequence variation in S-antigen genes of Plasmodium falciparum.  |  Brown, H., et al. 1987. Mol Biol Med. 4: 365-76. PMID: 3325726
10. The S-antigen of Plasmodium falciparum: repertoire and origin of diversity.  |  Bickle, Q., et al. 1993. Mol Biochem Parasitol. 61: 189-96. PMID: 8264723

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-S-antigen Antibody (PFS-1) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

S-antigen Antibody (PFS-1) Specifications

Alternate Product Name: S-antigen

Product Clone Name: PFS-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: S-antigen

Epitope Species: Plasmodium falciparum

Product Reactivity/Detection: S-antigen of P. falciparum

Species Reactivity/Detection: Plasmodium falciparum

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for S-antigen Antibody (PFS-1): N/A