Resmethrin CAS: 10453-86-8
MF: C22H26O3
MW: 338.45
A neural Ca2+-calmodulin-dependent protein phosphatase inhibitor.

Resmethrin (CAS 10453-86-8)

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Applicazione: Resmethrin is a neural Ca2+-calmodulin-dependent protein phosphatase inhibitor
Numero CAS: 10453-86-8
Peso molecolare: 338.45
Formula molecolare: C22H26O3
Informazioni supplementari: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
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Resmethrin has been reported to be a potent inhibitor of the neural calcium-calmodulin-dependent protein phosphatase, calcineurin, in bovine brain models. This compound has also been shown to eliminate constitutive nitric oxide release from lobster heart. Other studies have noted that Resmethrin inhibits the ATP dependent uptake of Ca2+ and displaces Ca2+ from crude synaptosomal membranes of rat brain in vitro.


Referenze

1. Doherty, J.D., et al. 1986. Comp. Biochem. Physiol. C. 84: 373-379. PMID: 2427274
2. Enan, E. and Matsumura, F. 1992. Biochem. Pharmacol. 43: 1777-1784. PMID: 1315545
3. Casares, F.M., et al. 2006. Med. Sci. Monit. 12: BR373-BR378. PMID: 17136001

Stato fisico :
Solid
Solubilità :
Soluble in DMSO or 100% ethanol; insoluble in water.
CONSERVAZIONE :
Store at 4° C
Punto di scioglimento :
43-48° C
Punto di ebollizione :
174° C at 1.05 mmHg
Densità :
0.96 g/cm3 at 20° C
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
RTECS :
GZ1310000
PubChem CID :
Numero MDL :
MFCD00041806
Numero EC :
233-940-7
Registro Beilstein :
1626510
SMILES :
CC(=CC1C(C1(C)C)C(=O)OCC2=COC(=C2)CC3=CC=CC=C3)C

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