PTP1B Substrate MW: 1330.3
A synthetic substrate for PTP1B.

PTP1B Substrate

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Nomi alternativi: DADEpYLIPQQG; [pTyr992] EGF receptor (988-998)
Applicazione: PTP1B Substrate is a synthetic substrate for PTP1B
Purezza: ≥92%
Peso molecolare: 1330.3
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
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PTP1B Substrate (DADEpYLIPQQG) is a biologically active peptide derived from an autophosphorylation site (Tyr992) of epidermal growth factor receptor (EGFR). An excellent synthetic substrate for mammalian PTP1B and Yersinia PTPase. May be used in non-radioactive phosphatase assays for colorimetric phosphate quantitation.


Referenze

1. Martin, B., Pallen, C.J., Wang, J.H. and Graves, D.J. 1985. Use of fluorinated tyrosine phosphates to probe the substrate specificity of the low molecular weight phosphatase activity of calcineurin. J. Biol. Chem. 260(28): 14932-14937. PMID: 2415511
2. Zhang, Z.Y., Maclean, D., Thieme-Sefler, A.M., Roeske, R.W. and Dixon, J.E. 1993. A continuous spectrophotometric and fluorimetric assay for protein tyrosine phosphatase using phosphotyrosine-containing peptides. Anal. Biochem. 211(1): 7-15. PMID: 7686722
3. Zhang, Z.Y., Thieme-Sefler, A.M., Maclean, D., McNamara, D.J., Dobrusin, E.M., Sawyer, T.K. and Dixon, J.E. 1993. Substrate specificity of the protein tyrosine phosphatases. Proc. Natl. Acad. Sci. U.S.A. 90(10): 4446-4450. PMID: 7685104
4. Harder, K.W., Owen, P., Wong, L.K., Aebersold, R., Clark-Lewis, I. and Jirik, F.R. 1994. Characterization and kinetic analysis of the intracellular domain of human protein tyrosine phosphatase beta (HPTP beta) using synthetic phosphopeptides. Biochem. J. 298(Pt2) : 395-401. PMID: 8135747
5. Sarmiento, M., Zhao, Y., Gordon, S.J. and Zhang, Z.Y. 1998. Molecular basis for substrate specificity of protein-tyrosine phosphatase 1B. J. Biol. Chem. 273(41): 26368-26374. PMID: 9756867

Aspetto :
Lyophilized powder
Stato fisico :
Solid
Sequenza :
Asp-Ala-Asp-Glu-pTyr-Leu-Ile-Pro-Gln-Gln-Gly
Solubilità :
Soluble in water.
CONSERVAZIONE :
Store at -20° C
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.

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PTP1B Substrate  Citazioni prodotti

Vedi quanti altri hanno usato PTP1B Substrate. Clicca sulla voce per laccesso a PubMed .

Ciatazioni 1 a3 di 3 totali

PMID: # 24668740  2014. Molecular nutrition & food research. 58: 1177-89.

PMID: # 22824864  Kimura, K. et al. 2012. Free radical biology & medicine. 53: 1239-51.

PMID: # 18579758  Kakazu, A. et al. 2008. Investigative ophthalmology & visual science. 49: 2927-35.

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