PtdIns-(5)-P1 (1,2-dioctanoyl) (ammonium salt)

The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids, but they play a critical role in the generation and transmission of cellular signals. PtdIns-(5)-P1 (1,2-dioctanoyl) is a synthetic analog of natural PtdIns featuring saturated C8:0 fatty acids at sn-1 and sn-2 positions. The compound features the same inositol and diacylglycerol (DAG) stereochemistry as that of the natural compound. PtdIns-(5)-P1 can be phosphorylated to di- (PtdIns-P2; PIP2) and triphosphates (PtdIns-P3; PIP3) by phosphoinositol (PI)-specific kinases. Hydrolysis of PtdIns-(4,5)-P2 by PI-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.

Referenze

1. Exton, J.H. 1996. Annu. Rev. Pharmacol. Toxicol. 36: 481-509. PMID: 8725399
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