Pregnenolone CAS: 145-13-1
MF: C21H32O2
MW: 316.48
A prohormone neurosteroid also a precursor to gonadal steroid hormones and the adrenal corticosteroids.

Pregnenolone (CAS 145-13-1)

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Nomi alternativi: Δ5-Pregenen-3β-ol-20-one; 3β-Hydroxy-5-pregenen-20-one; Arthenolone; Skinostelon; Enelone; Pregnetan; Pregneton; Pregnolon; Prenolon; Regnosone
Applicazione: Pregnenolone is an prohormone neurosteroid also a precursor to gonadal steroid hormones and the adrenal corticosteroids
Numero CAS: 145-13-1
Peso molecolare: 316.48
Formula molecolare: C21H32O2
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
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Pregnenolone is an endogenous neurosteroid that is involved in the steroidogenesis of progesterone, glucocorticoids, mineralocorticoids, androgens, and estrogens, making it a prohormone. It has been observed to inhibit GABA-gated chloride currents by enhancing receptor desensitization. Pregnenolone is an inhibitor of GABA Receptor and an activator of PXR.


Referenze

Shen W, Mennerick S, Covey DF, Zorumski CF. J Neurosci. 20:3571-9 (2000). Cascio C, Guarneri R, Russo D et al. J Neurochem. 74:2380-91(Grigoryev DN, Long BJ, Njar VC, Brodie AH. J Steroid Biochem Mol Biol. 75:1-10 (2000).

Aspetto :
Powder
Stato fisico :
Solid
Solubilità :
Soluble in ethanol (22 mg/ml at 25° C), chloroform, and DMSO (22 mg/ml at 25° C). Insoluble in water.
CONSERVAZIONE :
Store at 4° C
Punto di scioglimento :
190-192° C
Punto di ebollizione :
443.26° C at 760 mmHg (Predicted)
Densità :
1.09 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.55 (Predicted)
Attività ottica :
α20/D 28.5°±1.5°, c = 1 in ethanol
IC50 :
G6PD: IC50 = 81.4 µM (human); CYP51A1: IC50 = >200 µM (human)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
RTECS :
TU5560700
PubChem CID :
Indice Merck :
14: 7733
Numero MDL :
MFCD00003628
Numero EC :
205-647-4
Registro Beilstein :
2059026

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