PPACK dihydrochloride CAS: 142036-63-3
MF: C21H31ClN6O3•2HCl
MW: 523.88

PPACK dihydrochloride (CAS 142036-63-3)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 130ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
PPACK dihydrochloride is rated 5.0 out of 5 by 3.
loading
5
3
4
0
3
0
2
0
1
0
Nomi alternativi: PPACK dihydrochloride is also known as D-Phe-Pro-Arg-CMK.
Applicazione: PPACK dihydrochloride is an irreversible, potent, selective inhibitor of thrombin and its downstream effects.
Numero CAS: 142036-63-3
Peso molecolare: 523.88
Formula molecolare: C21H31ClN6O32HCl
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
loading

PPACK dihydrochloride is known to be an irreversible and potent inhibitor of thrombin. PPACK dihydrochloride is shown to inhibit thrombin activation of progelatinase A. In vivo pretreatment with PPACK dihydrochloride has been shown to inhibit thrombin-induced cerebral thromboembolism. PPACK dihydrochloride is also known to act as an anticoagulant in platelet-rich plasma. PPACK dihydrochloride is also known as D-Phenylalanyl-prolyl-arginyl Chloromethyl Ketone, D-Phe-Pro-Arg-CMK, and D-Phe-Pro-Arg-chloromethylketone.


Referenze

1. Liu, J.T. 1994. Eur. J. Pharmacol. 264(2): 183-190. PMID: 7851481 2. Rahr, H.B. 1994. Thromb. Res. 73(5): 279-284. PMID: 8016814 3. Zucker, S. 1995. J. Biol. Chem. 270(40): 23730-23738. PMID: 7559545 4. Kereiakes, D.J. 2001. J. Thromb. Thrombolysis. 12

Stato fisico :
Solid
Sequenza :
D-Phe-Pro-Arg-chloromethylketone
Solubilità :
Soluble in water (0.3 mg/ml at 25° C).
CONSERVAZIONE :
Store at -20° C
Indice di rifrazione :
n20D 1.64
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
PubChem CID :
SMILES :
C1C[[email protected]](N(C1)C(=O)[[email protected]@H](CC2=CC=CC=C2)N)C(=O)N[[email protected]@H](CCCN=C(N)N)C(=O)CCl.Cl.Cl

Download SDS (MSDS)

CERTIFICATO DI ANALISI

Adobe Acrobat Reader necessario per una visualizzazione affidabile,
stampa e commenta sui documenti PDF

PPACK dihydrochloride (CAS 142036-63-3)  Citazioni prodotti

Vedi quanti altri hanno usato PPACK dihydrochloride (CAS 142036-63-3). Clicca sulla voce per laccesso a PubMed .

Ciatazioni 1 a10 di 21 totali

PMID: # 34122402  Garishah, FM.|Rother, N.|Riswari, SF.|Alisjahbana, B.|Overheul, GJ.|van Rij, RP.|van der Ven, A.|van der Vlag, J.|de Mast, Q.| et al. 2021. Front Immunol. 12: 629167.

PMID: # 30722079  Yu, X. et al. 2019. Thromb. Haemost. 119: 586-593.

PMID: # 31423724  Ferrière, S.|Kawecki, C.|Ottavi, JF.|Denis, CV.|Kauskot, A.|Christophe, OD.|Lenting, PJ.| et al. 2019. J Thromb Haemost. 17: 2035-2046.

PMID: # 30560697  Rigg, RA. et al. 2019. Platelets. 30: 126-135.

PMID: # 30460241  Tullemans, BME. et al. 2018. Front Cardiovasc Med. 5: 142.

PMID: # 29785664  Zilberman-Rudenko, J.|Zhao, FZ.|Reitsma, SE.|Mitrugno, A.|Pang, J.|Shatzel, JJ.|Rick, B.|Tyrrell, C.|Hasan, W.|McCarty, OJT.|Schreiber, MA.| et al. 2018. Cardiovasc Eng Technol. 9: 515-527.

PMID: # 28083075  Zilberman-Rudenko, J.|Itakura, A.|Maddala, J.|Baker-Groberg, SM.|Vetter, R.|Tucker, EI.|Gruber, A.|Gerdes, C.|McCarty, OJ.| et al. 2016. Cell Mol Bioeng. 9: 496-508.

PMID: # 26725377  Zhu, S. et al. 2016. J. Thromb. Haemost. 14: 1070-81.

PMID: # 27816455  Streng, AS. et al. 2016. Biochem. Biophys. Res. Commun. 481: 165-168.

PMID: # 25418346  Jiménez-Alcázar, M. et al. 2015. J. Thromb. Haemost. 13: 732-42.

Ciatazioni 1 a10 di 21 totali
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 131ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 9ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;