PI-3,4-P2, 5NH4, PIP2, Dipalmitoyl-
PI-3,4-P2, 5NH4, PIP2, Dipalmitoyl- activates Ca2+-insensitive PKCδ, PKCε, and PKCη. Also activates Akt3, a serine/threonine kinase (also known as PKBα or Racα) by directly interacting with the Akt plekstrin homology (PH) domain.
Referenze
1. Toker, A., et al., 1994. Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3. The Journal of biological chemistry. 269(51): 32358-67. PMID: 7798235
2. Ireton, K., et al., 1996. A role for phosphoinositide 3-kinase in bacterial invasion. Science (New York, N.Y.). 274(5288): 780-2. PMID: 8864117
3. Franke, T F., et al., 1997. Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science (New York, N.Y.). 275(5300): 665-8. PMID: 9005852
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