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Phomopsin A | CAS 64925-80-0 | SCBT - Santa Cruz Biotechnology
Phomopsin A CAS: 64925-80-0
MF: C36H45ClN6O12
MW: 789.20

Phomopsin A (CAS 64925-80-0)

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Nomi alternativi: Phomopsin A is also known as NSC 381839.
Applicazione: Phomopsin A is a peptide mycotoxin and potent microtubule inhibitor that interacts near the vinblastine binding site.
Numero CAS: 64925-80-0
Purezza: >98%
Peso molecolare: 789.20
Formula molecolare: C36H45ClN6O12
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
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Phomopsin A, a peptide mycotoxin originally derived from Phomopsis leptostromiformis, has been shown to be a potent microtubule inhibitor. Mechanistic studies surrounding Phomopsin A suggest that the inhibition of polymerization of tubulin takes place via suppression of [3H]vinblastine binding to tubulin and enhancement of Colchicine (sc-203005) to tubulin. More specific studies report that Phomopsin A exerts its action on tubulin through interaction near the vinblastine binding site. Phomopsin A blocks microtubule growth, modulates the dynamics of microtubules, and interferes with mitosis.


Referenze

1. Lacey, E., et al. 1987. Biochem. Pharmacol. 36: 2133-2138. PMID: 3606630

2. Ludueña, R.F., et al. 1990. Biochem. Pharmacol. 39: 1603-1608. PMID: 2337418

3. Chaudhuri, A.R., et al. 1997. J. Protein Chem. 16: 99-105. PMID: 9112603

Stato fisico :
Solid
Derivato da :
Phomposis leptostromiformis
Solubilità :
Soluble in ethanol, methanol, DMF or DMSO. Slightly soluble in water.
CONSERVAZIONE :
Store at -20° C
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
RTECS :
SY2593000
PubChem CID :
SMILES :
CCC(=C(C(=O)NC(=CC(=O)O)C(=O)O)NC(=O)C1C=CCN1C(=O)C2C(OC3=C(C(=CC(=C3)C(C(C(=O)NC(C(=O)N2)C(=C)C)NC)O)Cl)O)(C)CC)C

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