Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Paraneoplastic pemphigus (PNP) is an autoimmune blistering disease that is associated with underlying neoplasms. PNP sera reacts with multiple plakin family proteins, among which only envoplakin and periplakin are constantly detected. Periplakin, a membrane-associated precursor of the epidermal cornified envelope and desmosomes, is a member of the plakin family of proteins. The periplakin gene PPL is mapped to human chromosome 16p13.3, and its promoter contains multiple AP2 sites and a SP1 site. Periplakin localizes to desmosomes, the interdesomosomal plasma membrane and intermediate filaments. The periplakin rod domain is necessary for the redistribution of envoplakin to desmosomes and the cytoskeleton by heterodimerization. The periplakin linker domain is required for intermediate filament association. The N-terminus of periplakin accumulates at the cell surface of microvilli in association with cortical actin. Envoplakin and periplakin localize independently to desmosomes, and the distribution of envoplakin at the interdesmosomal plasma membrane depends on heterodimerization with periplakin. The N-terminus of periplakin, therefore, plays an important role in forming the scaffold on which the cornfied envelop is assembled.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
What is the recommended secondary for periplakin (AE11): sc-80605 monoclonal antibody?
Richiesta da: Germaine
Thank you for your question. We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here:
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn