PD 173955 (CAS 260415-63-2)
Alternate Names:
PD173955 PD-173955 6-(2,6-dichlorophenyl)-8-methyl-2-((3-(methylthio)phenyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one Pd 173955
CAS Number:
260415-63-2
Molecular Weight:
443.40
Molecular Formula:
C21H16Cl2N4OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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PD 173955 (CAS 260415-63-2) References
- Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571). | Nagar, B., et al. 2002. Cancer Res. 62: 4236-43. PMID: 12154025
- Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinases. | Wisniewski, D., et al. 2002. Cancer Res. 62: 4244-55. PMID: 12154026
- Src activation regulates anoikis in human colon tumor cell lines. | Windham, TC., et al. 2002. Oncogene. 21: 7797-807. PMID: 12420216
- Phosphorylation of IkappaB-beta is necessary for neuronal survival. | Liu, L. and D'Mello, SR. 2006. J Biol Chem. 281: 1506-15. PMID: 16286457
- Structural insights into the ATP binding pocket of the anaplastic lymphoma kinase by site-directed mutagenesis, inhibitor binding analysis, and homology modeling. | Gunby, RH., et al. 2006. J Med Chem. 49: 5759-68. PMID: 16970400
- Induced disorder in protein-ligand complexes as a drug-design strategy. | Crespo, A. and Fernández, A. 2008. Mol Pharm. 5: 430-7. PMID: 18278867
- New effective inhibitors of the Abelson kinase. | Kraus, GA., et al. 2010. Bioorg Med Chem. 18: 6316-21. PMID: 20674368
- Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors. | Heinzlmeir, S., et al. 2017. ChemMedChem. 12: 999-1011. PMID: 28544567
- Development of Kinase Inactive PD173955 Analogues for Reducing Production of Aβ Peptides. | Sinha, A., et al. 2019. ACS Med Chem Lett. 10: 1430-1435. PMID: 31620229
- Pharmacoinformatics-based investigation of bioactive compounds of Rasam (South Indian recipe) against human cancer. | Kalimuthu, AK., et al. 2021. Sci Rep. 11: 21488. PMID: 34728718
Inhibitor of:
BASE, c-Src, Eph A8, Fap-1, Fyn, GRB7, GRIP-1, GRIP1, KIR2DS4, LOC388259, LRFN2, MAIR-II, p140Cap, Ran BP-5, Sck, Sin, TNK1, TULA, WAVE2, ZNF404, ZNF416, ZNF417, ZNF419, ZNF428, ZNF547, ZNF548, and ZNF609.Activator of:
Csk, and EphA10.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PD 173955, 10 mg | sc-507378 | 10 mg | $320.00 |