NNC 711 CAS: 145645-62-1
MF: C21H22N2O3•HCl
MW: 386.88
A potent and selective inhibitor of GABA T-1.

NNC 711 (CAS 145645-62-1)

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Nomi alternativi: NO-711 hydrochloride; 1,2,5,6-Tetrahydro-1-[2-[[(diphenylmethylene)amino]oxy] ethyl]-3-pyridinecarboxylic acid hydrochloride
Applicazione: NNC 711 is a potent and selective inhibitor of GABA T-1
Numero CAS: 145645-62-1
Purezza: ≥99%
Peso molecolare: 386.88
Formula molecolare: C21H22N2O3•HCl
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
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NNC 711 is a potent and selective inhibitor of GABA uptake by GABA T-1( (IC50 values are 0.04, 171, 1700 and 622 μM for hGABA T-1, rGABA T-2, hGABA T-3 and hBGT-1 respectively). GABA transporters belong to the solute carrier family 6 (SLC6) and are sodium- and chloride-dependent members that mediate the rapid removal of GABA. NNC 711 also exhibits cognition-enhancing activity.


Referenze

1. Suzdak, P.D., et al. 1992. Eur. J. Pharmacol. 224: 189-198.
2. Borden, L.A., et al. 1994. Eur. J. Pharmacol. 269: 219-224.
3. O'Connell, A.W., et al. 2001. Eur. J. Pharmacol. 424: 37-44.

Stato fisico :
Solid
Solubilità :
Soluble in water (≥10 mg/mL) at 60° C, ethanol (10 mM), and DMSO (100 mM).
CONSERVAZIONE :
Desiccate at 4° C
Punto di scioglimento :
204-206° C
Punto di ebollizione :
541.2° C at 760 mmHg (Predicted)
IC50 :
HGAT-1: IC50 = 0.04 µM ; RGAT-2: IC50 = 171 µM ; HGAT-3 : IC50 = 1700 µM ; HBGT-1: IC50 = 622 µM
Ki Data :
GABA transporter 1: Ki= 47 nM (Rattus norvegicus)
Valori pK :
pKa: 3.56 (Predicted), pKb: 7.76 (Predicted)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
PubChem CID :
Numero MDL :
MFCD00153853
SMILES :
C1CN(CC(=C1)C(=O)O)CCON=C(C2=CC=CC=C2)C3=CC=CC=C3.Cl

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