NNC 05-2090 hydrochloride CAS: 184845-43-0
MF: C27H30N2O2•HCl
MW: 451.01
A GABA uptake inhibitor displaying selectivity for BGT-1 (mGAT-2) transporters.

NNC 05-2090 hydrochloride (CAS 184845-43-0)

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Nomi alternativi: 1-[3-(9H-Carbazol-9-yl)propyl]-4-(2-methoxyphenyl)-4-piperidinol hydrochloride
Applicazione: NNC 05-2090 hydrochloride is a GABA uptake inhibitor displaying selectivity for BGT-1 (mGAT-2) transporters
Numero CAS: 184845-43-0
Purezza: ≥98%
Peso molecolare: 451.01
Formula molecolare: C27H30N2O2•HCl
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
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NNC 05-2090 hydrochloride is a GABA uptake inhibitor; displays moderate selectivity for BGT-1 (mGAT-2) transporters. GABA transporters belong to the solute carrier family 6 (SLC6) and are sodium- and chlorde-dependent members that mediate the rapid removal of GABA. NNC 05-2090 hydrochloride also displays affinity at α1- and D2-receptors (IC50 values are 266 and 1632 nM respectively). NNC 05-2090 hydrochloride is an inhibitor of GABA T-1, GABA T-2 and GABA T-3.


Referenze

1. Thomsen, C., et al. 1997. Br. J. Pharmacol. 120: 983-985. PMID: 9134205
2. Dalby, N.O., et al. 1997. Epilepsy Res. 28: 51-61. PMID: 9255599

Stato fisico :
Solid
Solubilità :
Soluble in DMSO (100 mM), and ethanol (13 mM).
CONSERVAZIONE :
Desiccate at room temperature
Indice di rifrazione :
n20D ~1.62 (Predicted)
IC50 :
α1- receptors: IC50 = 0.27 µM; BGT-1: IC50 = 1.4 µM (human); GABA transporter 3: IC50 = 1.41 µM (mouse); D2-receptors: IC50 = 1.63 µM; GABA transporter 1: IC50 = 10.23 µM (mouse)
Ki Data :
BGT-1: Ki= 1.4 µM (human); GABA T-3: Ki= 15 µM (human); GABA T-1: Ki= 19 µM (human); GABA T-2: Ki= 41 µM (human)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
PubChem CID :
Numero MDL :
MFCD00952020
SMILES :
COC1=CC=CC=C1C2(CCN(CC2)CCCN3C4=CC=CC=C4C5=CC=CC=C53)O.Cl

Download SDS (MSDS)

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