Nifuroxazide CAS: 965-52-6
MF: C12H9N3O5
MW: 275.22
An inhibitor of STAT activation and signaling activity.

Nifuroxazide (CAS 965-52-6)

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Nifuroxazide is rated 5.0 out of 5 by 1.
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Nomi alternativi: 5-Nitro-2-furaldehyde p-hydroxybenzoylhydrazone
Applicazione: Nifuroxazide is an inhibitor of STAT activation and signaling activity
Numero CAS: 965-52-6
Purezza: >97%
Peso molecolare: 275.22
Formula molecolare: C12H9N3O5
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
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Nifuroxazide is a nitrofuran compound inhibitor of STAT transcription factor signaling. Nifuroxazide is described to block constitutive phosphorylation of STAT3 by reducing Jak kinase autophosphorylation, decreasing the viability of myeloma cells depending on constitutive STAT3 activity for survival while not affecting normal peripheral blood mononuclear cells. Nifuroxazide produces decreases in tyrosine phosphorylation of Jak2 and Tyk2, and showed no effects on EGF receptor tyrosine kinase or Src kinase, indicating a relative specificity of Nifuroxazide for Jak2 and Tyk2. Nifuroxazide shows no inhibition of Akt or MAPK phosphorylation.


Referenze

1. Nelson, E.A., et al. 2008. Blood. 112: 5095-5102. PMID: 18824601

Aspetto :
Crystalline
Stato fisico :
Solid
Solubilità :
Soluble in water (practically insoluble), chloroform (practically insoluble), ethyl ether (0.01g/>100ml) (practically insoluble), Methanol (0.01g/100ml) (very slightly soluble), 1 N Sodium hydroxide (1.0g/30ml), and DMSO.
CONSERVAZIONE :
Store at 4° C
Punto di scioglimento :
201.97° C
Punto di ebollizione :
477.25° C (Predicted)
Densità :
~1.5 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.65
IC50 :
IL-6-induced STAT3: IC50 = 3 µM (U3A cells); tyr705 of STAT3: IC50 = 10 µM (U266 cells); Leishmania donovani: IC50 = 2.4 µM (Leishmania donovani); Plasmodium falciparum: EC5050 = 3.77 µM
Valori pK :
pKa: 8.36
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
RTECS :
DH2528300
PubChem CID :
Indice Merck :
14: 6535
Numero MDL :
MFCD00079482
Numero EC :
213-522-0
Registro Beilstein :
4264976
SMILES :
C1=CC(=CC=C1C(=O)N/N=C/C2=CC=C(O2)[N+](=O)[O-])O

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Nifuroxazide (CAS 965-52-6)  Citazioni prodotti

Vedi quanti altri hanno usato Nifuroxazide (CAS 965-52-6). Clicca sulla voce per laccesso a PubMed .

Ciatazioni 1 a4 di 4 totali

PMID: # 28949055  Osabe, M. et al. 2017. J Appl Toxicol.

PMID: # 26136413  Matsuo, Y. et al. 2015. Journal of cachexia, sarcopenia and muscle. 6: 62-72.

PMID: # 23095323  Jiang, X. et al. 2013. Clinical cancer research : an official journal of the American Association for Cancer Research. 19: 598-609.

PMID: # 18824601  Nelson, EA. et al. 2008. Blood. 112: 5095-5102.

Ciatazioni 1 a4 di 4 totali
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