Niclosamide Niclosamide is an inhibitor of the Stat3 signaling pathway and also a FRAP inhibitor.

Niclosamide (CAS 50-65-7)

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Nomi alternativi: 2′,5-Dichloro-4′-nitrosalicylanilide; 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Applicazione: Niclosamide is an inhibitor of the Stat3 signaling pathway and also a FRAP inhibitor
Numero CAS: 50-65-7
Peso molecolare: 327.12
Formula molecolare: C13H8Cl2N2O4
Informazioni supplementari: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
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Niclosamide is an inhibitor of the Stat3 signaling pathway. Niclosamide inhibits the activation, nuclear translocation and transactivation of Stat3. Niclosamide displays selectivity for Stat3 over Stat1, Stat5, JAK1, JAK2 and Src kinases. Niclosamide inhibits the transcription of Stat3 target genes and induces cell growth inhibition, apoptosis and cell cycle arrest of cancer cells with constitutively active Stat3. Niclosamide is also a FRAP inhibitor via reversible inhibition of mTORC1 signaling and stimulates autophagy in vitro. Niclosamide displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells.


Referenze

1. Balgi, Aruna D., et al., 2009. Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PloS one. 4(9): e7124. PMID: 19771169

2. Jin, Yanli., et al., 2010. Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappaB pathway and generation of reactive oxygen species. Cancer research. 70(6): 2516-27. PMID: 20215516

Aspetto :
Powder
Stato fisico :
Solid
Solubilità :
Soluble in ethanol (25 mM), DMSO (10 mM), chloroform (very slightly), and methanol: acetone (1: 1) (50 mg/ml). Insoluble in water.
CONSERVAZIONE :
Store at 4° C
Punto di scioglimento :
225-233° C
Punto di ebollizione :
~424.5° C at 760 mmHg (Predicted)
Densità :
~1.6 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.71 (Predicted)
IC50 :
STAT3: IC50 = 0.25 µM; Wnt3a from stimulating HEK293 cellular LEF/TCF transcription activity: IC50 = 0.5 µM; DU-145: IC50 = 0.7 µM (human); Dishevelled-2 downregulation: IC50 = ~1 µM; Flg: IC50 = 13.1 µM (human)
Valori pK :
pKa: 7.45 (Predicted)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
2
RTECS :
VN8400000
PubChem CID :
Indice Merck :
14: 6519
Numero MDL :
MFCD00057597
Numero EC :
200-056-8
Registro Beilstein :
2820605
SMILES :
C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O

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Niclosamide (CAS 50-65-7)  Citazioni prodotti

Vedi quanti altri hanno usato Niclosamide (CAS 50-65-7). Clicca sulla voce per laccesso a PubMed .

Ciatazioni 1 a4 di 4 totali

PMID: # 31451218  Biochem. Biophys. Res. Commun. 518: 638-643.

PMID: # 25465182  Vet Microbiol. 438-447.

PMID: # 30500562  Metab. Clin. Exp. 43-52.

PMID: # 25746684  Vet Microbiol. 370-7.

Ciatazioni 1 a4 di 4 totali
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