Neurokinin A CAS: 86933-74-6
MF: C50H80N14O14S
MW: 1133.33
An endogenous tachykinin agonist with preference for the NK-2R.

Neurokinin A (CAS 86933-74-6)

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Neurokinin A is rated 5.0 out of 5 by 1.
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Nomi alternativi: Substance K; Neuromedin L
Applicazione: Neurokinin A is an endogenous tachykinin agonist with preference for the NK-2R
Numero CAS: 86933-74-6
Peso molecolare: 1133.33
Formula molecolare: C50H80N14O14S
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
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Neurokinin A is a member of the endogenous tachykinin agonist with preference for the NK-2R (NK-2 receptor) with greater potency as a bronchoconstrictor than Substance P (sc-201169). The comound has shown to be identical to substance K and neuromedin L1. Neurokinin A has been reported to effect reproduction by controlling at the hypothalamus level gonadotropin and prolactin secretion along with steroid secretion at the ovarian and gonadal level. An increase in inositol 1,4,5-trisphosphate (IP3) levels along with paralleled increase in intracellular free Ca2+ in BHK-21 cells with the NK-2R gene were stimulated with Neurokinin A. The compound has also been observed to induce contraction in muscle strips and single cells of the human sigmoid colon circular muscle. Neurokinin A has also been used to discover the location of tachykinin receptors.


Referenze

1. Eistetter, H.R., et al. 1993. J. Cell. Biochem. 52: 84-91. PMID: 8391539
2. Debeljuk, L. and Lasaga, M. 1999. Peptides. 20: 285-299. PMID: 10422885
3. Cao, W., et al. 2000. Gastroenterology. 119: 51-61. PMID: 10889154

Stato fisico :
Solid
Solubilità :
Soluble in water (1 g/l) at 20° C, 10% acetonitrile / water (1 mg/ml), and 5% Acetic Acid.
CONSERVAZIONE :
Store at -20° C
Punto di ebollizione :
~1610.7° C at 760 mmHg (Predicted)
Densità :
~1.3 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.58
Attività ottica :
α20/D -57.4°, c = 0.37 in 1 M AcOH
IC50 :
Neurokinin 2 receptor: IC50 = 1 nM (human); Neurokinin 1 receptor: IC50 = 3.5 nM (human); Neurokinin 3 receptor: IC50 = 45 nM (human)
Ki Data :
Neurokinin 2 receptor: Ki= 0.71 nM (human); Neurokinin 1 receptor: Ki= 630 nM (human)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
PubChem CID :
Numero MDL :
MFCD00167560
SMILES :
CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N

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